5-{5-[(1-isopropylpiperidin-4-yl)oxy]-1,3-dihydro-1'H-spiro[indene-2,4'-piperidin]-1'-yl}-N-methylpyrazine-2-carboxamide | 1133285-94-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 5-{5-[(1-isopropylpiperidin-4-yl)oxy]-1,3-dihydro-1'H-spiro[indene-2,4'-piperidin]-1'-yl}-N-methylpyrazine-2-carboxamide
• 英文别名: N-methyl-5-[5-(1-propan-2-ylpiperidin-4-yl)oxyspiro[1,3-dihydroindene-2,4'-piperidine]-1'-yl]pyrazine-2-carboxamide
• CAS: 1133285-94-5
• 化学式: C₂₇H₃₇N₅O₂
• 分子量: 463.623
• InChiKey: XTKSLJZTNJRAPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  70.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• SUBSTITUTED ARYL-FUSED SPIROCYCLIC AMINES
  申请人：Xu Yuelian

  公开号：US20100317679A1

  公开（公告）日：2010-12-16

  Substituted Aryl-fused Spirocyclic Amines of the formula (I): are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

  提供公式(I)的取代芳基螺环胺类化合物，以及其制备和使用方法。这种化合物通常可用于体内或体外调节组胺H3受体的配体结合，并且在治疗人类、家畜伴侣动物和家畜动物的各种疾病方面特别有用。提供了药物组合物和治疗方法，以及用于检测组胺H3受体（例如受体定位研究）的配体的使用方法。
• [EN] SUBSTITUTED ARYL-FUSED SPIROCYCLIC AMINES<br/>[FR] AMINES SPIROCYCLIQUES ARYL-CONDENSÉES SUBSTITUÉES
  申请人：NEUROGEN CORP

  公开号：WO2009039431A2

  公开（公告）日：2009-03-26

  Substituted Aryl-fused Spirocyclic Amines of the formula (I): are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).