N,N-bis(2-naphthyl)formamide | 1392275-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-bis(2-naphthyl)formamide
• 英文别名: N,N-dinaphthalen-2-ylformamide
• CAS: 1392275-94-3
• 化学式: C₂₁H₁₅NO
• 分子量: 297.356
• InChiKey: IVDRYEWKSZPXAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-bis(2-naphthyl)formamide 在 4-二甲氨基吡啶 、 三氯硅烷 、 sulfur 作用下， 以 甲苯 为溶剂， 反应 18.0h， 以100%的产率得到N,N-bis(2-naphthyl)thioformamide
  参考文献：
  名称：

  N,N-Diarylthiazol-5-amines: Structure-Specific Mechanofluorochromism and White Light Emission in the Solid State

  摘要：

  摘要 开发了一系列在噻唑环上具有 4-吡啶基的 N,N-二芳基噻唑-5-胺，并阐明了它们的光物理特性。它们的合成是通过将我们的方法应用于 N-芳基甲基仲硫酰胺和 N,N-二芳基硫代甲酰胺的组合而实现的。这使我们获得了在氮原子上带有不同类型芳香基团的胺。我们研究了它们在溶液中的吸收和发射光谱。4 吡啶基赋予胺更高的极性。此外，还对这些胺的固态发射进行了评估。有几种胺显示出机械氟变色（MFC）。噻唑环上的 4-吡啶基是表现 MFC 特性的必要条件。虽然通过研磨原始粉末，N-(5-噻唑基) N,N-二(2-萘基)胺并没有显示出 MFC，但当研磨粉末与丙酮蒸气熏蒸时，却观察到了白光发射。

  DOI：

  10.1246/bcsj.20200083
• 作为产物：
  描述：

  甲酸 、 2,2-二萘胺 反应 6.0h， 生成 N,N-bis(2-naphthyl)formamide
  参考文献：
  名称：

  On the Formation and ¹H NMR-spectroscopic Characterization of N,N-Diaryl-substituted Formamide Chlorides

  摘要：

  N,N-二芳基取代甲酰胺与草酸氯酰发生反应，不会形成预期的盐类状甲酰胺氯化物，而是形成相应的非离子性N-二氯甲基取代的二芳胺。

  DOI：

  10.1515/znb-2012-0401

文献信息

• CHARGE CONTROL AGENT AND RELATED ART
  申请人：Kuroda Kazuyoshi

  公开号：US20090053641A1

  公开（公告）日：2009-02-26

  [PROBLEMS] Providing a charge control agent that has a negative charge providing property at a practical level, is colorless to light-colored and usable in color toners, produces static charges stable to environmental changes by electrifying the resin powder of a toner and the like, is excellent in storage stability and durability, and is highly safe, as well as a method of controlling the charge of resin powder using the charge control agent, and a toner. [MEANS OF SOLVING THE PROBLEMS] A charge control agent having a compound represented by the formula shown below as the active ingredient, as well as a method of controlling the charge of resin powder using the charge control agent, and a toner. X: an oxygen atom or N—H; Each of R 1 to R 4 : a hydrogen atom, a carboxyl group, an aminocarbonyl group having or not having a substituent, an aminocarbonylmethyl group having or not having a substituent, an alkoxycarbonyl group, an alkyl group, a phenyl group having a substituent or not having a substituent, or a group that forms a saturated or unsaturated ring having or not having a substituent in cooperation with any other group selected from among R 1 to R 4 .

  [问题] 提供一种在实际水平上具有负电荷提供特性的充电控制剂，无色至浅色并可用于彩色调色剂，通过电化树脂粉末等产生稳定的静电荷，具有优异的储存稳定性和耐久性，并且非常安全，以及使用该充电控制剂控制树脂粉末电荷的方法和调色剂。 [解决问题的方法] 提供一种具有以下公式所示化合物作为活性成分的充电控制剂，以及使用该充电控制剂控制树脂粉末电荷的方法和调色剂。 X：氧原子或N-H； R1至R4中的每一个：氢原子，羧基，具有或不具有取代基的氨基羰基，具有或不具有取代基的氨基羰基甲基，烷氧羰基，烷基，具有或不具有取代基的苯基，或与R1至R4中选择的任何其他基团相互配合形成饱和或不饱和环的基团。
• Fused pyramidine derivative and use thereof
  申请人：Hamamura Kazumasa

  公开号：US20070010537A1

  公开（公告）日：2007-01-11

  There are provided a fused pyrimidine compound having antagonistic activity against luteinizing hormone releasing hormone, and a medicine containing the compound. A luteinizing hormone releasing hormone antagonist containing a compound represented by the formula: wherein R 1a is a hydrocarbon group which may be substituted or a hydrogen atom, ring A a is a 6-membered aromatic ring which may be further substituted, ring B a is a homocyclic or heterocyclic ring which may be further substituted, W a is an oxygen atom or a sulfur atom, X a1 and X a2 , which may be identical or different, are each a hydrogen atom, a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted, or X a1 and X a2 together may form an oxygen atom, a sulfur atom or NR 3a (wherein R 3a is a hydrocarbon group which may be substituted or a hydrogen atom), and Y a is C 1-6 alkylene which may be substituted or a bond, or a salt or prodrug thereof.

  提供了一种融合嘧啶化合物，具有抗促黄体激素释放激素的拮抗活性，以及含有该化合物的药物。一种促黄体激素释放激素拮抗剂，包含以下式子所代表的化合物：其中，R1a是一个可以被取代的碳氢基团或氢原子，环A是一个可以进一步取代的6元芳香环，环B是一个可以进一步取代的同环或异环，Wa是一个氧原子或硫原子，Xa1和Xa2，可能相同或不同，是每个可以被取代的碳氢基团或杂环基团，或Xa1和Xa2在一起可以形成氧原子、硫原子或NR3a（其中R3a是一个可以被取代的碳氢基团或氢原子），而Y是C1-6烷基，可以被取代或成为键，或其盐或前药。
• FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF
  申请人：Hamamura Kazumasa

  公开号：US20090062258A1

  公开（公告）日：2009-03-05

  The present invention provides a compound represented by the formula (I) and a salt thereof wherein: ring A is a 5-membered aromatic heterocycle optionally having substituent(s); R 1 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); W is an oxygen atom or a sulfur atom; X 1 and X 2 may be the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s) or a heterocyclic group, or, X 1 and X 2 in combination, optionally, form an oxygen atom, a sulfur atom or ═NR 2 ; ring B is an aromatic ring optionally further having substituent(s); Y is a bond, C 1-6 alkylene C 2-6 alkenylene or C 2-6 alkynylene, optionally having substituent(s); and Z is —SO n R 3 or —COR 4 , which are useful as a pharmaceutical agent having GnRH antagonistic action.

  本发明提供了一种由式(I)表示的化合物及其盐，其中：环A是一个可选具有取代基的5元芳香杂环；R1是氢原子或一个可选具有取代基的碳氢基；W是氧原子或硫原子；X1和X2可以相同或不同，每个都是氢原子、可选具有取代基的碳氢基或杂环基，或者X1和X2组合，可选地形成氧原子、硫原子或═NR2；环B是一个可选进一步具有取代基的芳香环；Y是键，C1-6烷基C2-6烯基或C2-6炔基，可选具有取代基；Z是—SOnR3或—COR4，其作为具有GnRH拮抗作用的药物剂使用。
• CHARGE CONTROL AGENT AND RELATED TECHNIQUE
  申请人：ORIENT CHEMICAL INDUSTRIES, LTD.

  公开号：EP1862860A1

  公开（公告）日：2007-12-05

  [PROBLEMS] Providing a charge control agent that has a negative charge providing property at a practical level, is colorless to light-colored and usable in color toners, produces static charges stable to environmental changes by electrifying the resin powder of a toner and the like, is excellent in storage stability and durability, and is highly safe, as well as a method of controlling the charge of resin powder using the charge control agent, and a toner. [MEANS OF SOLVING THE PROBLEMS] A charge control agent having a compound represented by the formula shown below as the active ingredient, as well as a method of controlling the charge of resin powder using the charge control agent, and a toner. X : an oxygen atom or N-H; Each of R1 to R4 : a hydrogen atom, a carboxyl group, an aminocarbonyl group having or not having a substituent, an aminocarbonylmethyl group having or not having a substituent, an alkoxycarbonyl group, an alkyl group, a phenyl group having a substituent or not having a substituent, or a group that forms a saturated or unsaturated ring having or not having a substituent in cooperation with any other group selected from among R1 to R4.

  [问题] 提供一种电荷控制剂，该电荷控制剂在实用水平上具有提供负电荷的特性，无色至浅 色，可用于彩色调色剂，通过对调色剂的树脂粉末等通电产生对环境变化稳定的静电荷，储 存稳定性和耐久性优异，安全性高，以及使用该电荷控制剂控制树脂粉末电荷的方法和调色 剂。 [解决问题的方法]一种电荷控制剂，其有效成分为下式所示的化合物，以及一种使用该电荷控制剂控制树脂粉电荷的方法和一种调色剂。 X ：氧原子或 N-H； R1 至 R4 中的每一个：氢原子、羧基、具有或不具有取代基的氨基羰基、具有或不 具有取代基的氨基羰甲基、烷氧基羰基、烷基、具有或不具有取代基的苯基、或与选 自 R1 至 R4 的任何其他基团配合形成具有或不具有取代基的饱和或不饱和环的基团。
• FUSED PYRIMIDINE DERIVATIVE AND USES THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1847541A1

  公开（公告）日：2007-10-24

  A compound represented by the formula (I) wherein ring A is a 5-membered aromatic heterocycle optionally having substituent(s), R1 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), W is an oxygen atom or a sulfur atom, X1 and X2 may be the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s) or a heterocyclic group, or, X1 and X2 in combination optionally form an oxygen atom, a sulfur atom or =NR2, ring B is an aromatic ring optionally further having substituent(s), Y is a bond, C1-6 alkylene C2-6 alkenylene or C2-6 alkynylene, optionally having substituent(s), and Z is a group represented by formula: -SOnR3, or a group represented by formula: -COR4, or a salt thereof, is useful as a pharmaceutical agent having GnRH antagonistic action.

  由式 (I) 代表的化合物 其中环 A 是可选具有取代基的 5 元芳香杂环、 R1 是氢原子或可选具有取代基的烃基、 W 是氧原子或硫原子、 X1 和 X2 可以相同或不同，各自为氢原子、可选具有取代基的烃基或杂环基，或者，X1 和 X2 组合可选形成氧原子、硫原子或 =NR2、 环 B 是芳香环，可选择进一步具有取代基、 Y 是键、C1-6 亚烷基、C2-6 亚烯基或 C2-6 亚炔基，可选择具有取代基，以及 Z 是由式-SOnR3，或由式表示的基团：-COR4，或其盐，可用作具有 GnRH 拮抗作用的药剂。