8-(4-fluoro-2,6-dimethylphenylamino)-4-methyl-2H-phthalazin-1-one | 1072157-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-(4-fluoro-2,6-dimethylphenylamino)-4-methyl-2H-phthalazin-1-one
• 英文别名: 8-(4-fluoro-2,6-dimethylanilino)-4-methyl-2H-phthalazin-1-one
• CAS: 1072157-20-0
• 化学式: C₁₇H₁₆FN₃O
• 分子量: 297.332
• InChiKey: UCJHTOJQFVMALG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  53.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• TREATMENT OF FAMILIAL EXUDATIVE VITREORETINOPATHY THROUGH S1PR2 INHIBITION
  申请人：Dalhousie University

  公开号：EP3148550A1

  公开（公告）日：2017-04-05
• [EN] BLOCKERS OF THE NOGO-A S1PR PATHWAY FOR THE TREATMENT OF DISEASES CHARACTERIZED BY NEURONAL DAMAGE AND LACK OF SUBSEQUENT REPAIR<br/>[FR] BLOQUEURS DE LA VOIX NOGO-A S1PR POUR LE TRAITEMENT DE MALADIES CARACTÉRISÉES PAR UNE LÉSION NEURONALE ET UN DÉFAUT DE RÉPARATION ULTÉRIEURE
  申请人：UNIV ZUERICH

  公开号：WO2012164103A2

  公开（公告）日：2012-12-06

  The present invention provides inhibitors capable of binding to a member of the S1PR receptor group comprised of S1PR2 and S1PR5 with a dissociation constant of 5x10-7 mol/l or smaller for treating neuronal damage, specifically an antibody, an antibody fragment, an antibody-like molecule, a nucleic acid aptamer or an oligopeptide with 6 to 30 amino acid residues in length. Similarly, an interfering RNA or an antisense modulator of gene expression of G13 or a member of the S1PR receptor group described above are provided for treating of neuronal damage.
• [EN] TREATMENT OF FAMILIAL EXUDATIVE VITREORETINOPATHY THROUGH S1PR2 INHIBITION<br/>[FR] TRAITEMENT DE LA VITRÉORÉTINOPATHIE EXSUDATIVE FAMILIALE PAR INHIBITION DE S1PR2
  申请人：UNIV DALHOUSIE

  公开号：WO2015184541A1

  公开（公告）日：2015-12-10

  Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP) through the administration of a therapeutically effective amount of a Sphingosine-1-phosphate receptor type 2 (S1PR2) inhibitor.