N-[5-({4-[({2-[methyl(methylsulfonyl)amino]pyridin-3-yl}methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)pyridin-2-yl]acetamide | 1073156-23-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[5-({4-[({2-[methyl(methylsulfonyl)amino]pyridin-3-yl}methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)pyridin-2-yl]acetamide
• 英文别名: US10450297, Example 102；N-[5-[[4-[[2-[methyl(methylsulfonyl)amino]pyridin-3-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]pyridin-2-yl]acetamide
• CAS: 1073156-23-6
• 化学式: C₂₀H₂₁F₃N₈O₃S
• 分子量: 510.5
• InChiKey: QQTCCOAGTGEJBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  151
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
  申请人：Luzzio Michael Joseph

  公开号：US20090054395A1

  公开（公告）日：2009-02-26

  The present invention relates to a compound of the formula I wherein R 1 to R 6 , A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

  本发明涉及一种具有以下式I的化合物 其中R 1 至R 6 ，A，B，n和m如本文所定义。这种新型磺酰胺衍生物在治疗哺乳动物（如癌症）中的异常细胞生长方面是有用的。本发明还涉及一种在治疗哺乳动物（尤其是人类）中的异常细胞生长中使用这种化合物的方法，以及含有这种化合物的药物组合物。
• [EN] DIAMINOPYRIDINES FOR THE TREATMENT OF DISEASES WHICH ARE CHARACTERISED BY EXCESSIVE OR ANOMAL CELL PROLIFERATION<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009071535A1

  公开（公告）日：2009-06-11

  The present invention encompasses compounds of general formula (1) wherein A, B, R1- R3, Rx and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）中A，B，R1-R3，Rx和n如权利要求1中所定义的化合物，适用于治疗由过度或异常细胞增殖特征的疾病，并且它们用于制备具有上述特性的药物。
• DIAMINOPYRIDINES FOR THE TREATMENT OF DISEASES WHICH ARE CHARACTERISED BY EXCESSIVE OR ANOMAL CELL PROLIFERATION
  申请人：Sapountzis Ioannis

  公开号：US20100305099A1

  公开（公告）日：2010-12-02

  The present invention encompasses compounds of general formula (1) wherein A, B, R 1 -R 3 , Rx and n are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）中A、B、R1-R3、Rx和n如权利要求1所定义的化合物，适用于治疗由过度或异常细胞增殖所特征的疾病，并且它们的用途用于制备具有上述特性的药物。
• Sulfonyl amide derivatives for the treatment of abnormal cell growth
  申请人：Pfizer, Inc.

  公开号：US10450297B2

  公开（公告）日：2019-10-22

  The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

  本发明涉及一种式 I 的化合物 其中 R1 至 R6、A、B、n 和 m 如本文所定义。这种新型磺酰基酰胺衍生物可用于治疗哺乳动物的异常细胞生长，如癌症。本发明还涉及使用此类化合物治疗哺乳动物（尤其是人类）细胞异常生长的方法，以及含有此类化合物的药物组合物。
• US7928109B2
  申请人：——

  公开号：US7928109B2

  公开（公告）日：2011-04-19