3-Acetyl-1lambda6-thiolane-1,1-dione | 3895-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: 3-Acetyl-1lambda6-thiolane-1,1-dione
• 英文别名: 1-(1,1-dioxothiolan-3-yl)ethanone
• CAS: 3895-34-9
• 化学式: C₆H₁₀O₃S
• 分子量: 162.21
• InChiKey: SOMDLFMGMLQPER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] HETEROARYL NITRILE COMPOUNDS USEFUL AS INHIBITORS OF CATHEPSIN-S<br/>[FR] COMPOSÉS D'HÉTÉROARYL-NITRILE UTILES COMME INHIBITEURS DE CATHEPSINE-S
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2011109470A1

  公开（公告）日：2011-09-09

  Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.

  揭示了具有以下化学式（I）的Cathepsin-S可逆抑制剂化合物，可用于治疗自身免疫和其他疾病。还揭示了含有这些化合物的药物组合物，以及制备和使用这些化合物的方法。
• ADDITIVE FOR NONAQUEOUS ELECTROLYTE SOLUTIONS, NONAQUEOUS ELECTROLYTE SOLUTION AND ELECTRICITY STORAGE DEVICE
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：US20210184259A1

  公开（公告）日：2021-06-17

  Disclosed is an additive for a nonaqueous electrolyte solution, including a compound represented by the following formula (1): in formula (1), X represents a sulfonyl group or a carbonyl group, R 1 represents an alkyl group having 1 to 4 carbon atoms, which may be substituted with a halogen atom, a hydroxyl group, or the like, and R 2 represents a hydrocarbon group having 1 to 3 carbon atoms, which may be substituted with a halogen atom.

  本发明涉及一种非水电解质溶液的添加剂，包括以下式(1)所表示的化合物： 在式(1)中，X代表磺酰基或羰基，R1代表1至4个碳原子的烷基，可以被卤素原子、羟基或类似物取代，而R2代表1至3个碳原子的碳氢基团，可以被卤素原子取代。
• PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS
  申请人：Bristol-Myers Squibb Company

  公开号：US20160326108A1

  公开（公告）日：2016-11-10

  Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.