1-Amino-2-methylamino-pentan | 6084-48-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Amino-2-methylamino-pentan
• 英文别名: N2-Methylpentane-1,2-diamine；2-N-methylpentane-1,2-diamine
• CAS: 6084-48-6
• 化学式: C₆H₁₆N₂
• 分子量: 116.206
• InChiKey: YYUUOEQXJGQPIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• PROTEIN-POLYMER-DRUG CONJUGATES
  申请人：Mersana Therapeutics, Inc.

  公开号：EP3228325A1

  公开（公告）日：2017-10-11

  A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier comprising poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by Lp. Each occurrence of D is independently a therapeutic agent having a molecular weight ≤ 5 kDa, LD and Lp are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds comprising PHF useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates of their compositions.

  本文提供了一种药物共轭物。该共轭物包括基于蛋白质的识别分子（PBRM）和聚合物载体，聚合物载体包括被一个或多个-LD-D 取代的聚（1-羟甲基亚乙基羟甲基-甲醛）（PHF），基于蛋白质的识别分子通过 Lp 连接到聚合物载体上。每次出现的 D 都是分子量≤ 5 kDa 的独立治疗剂，LD 和 Lp 分别是连接治疗剂和 PBRM 与聚合物载体的连接体。还公开了包含PHF的聚合物支架，PHF可与PBRM共轭形成本文所述的聚合物-药物-PBRM共轭物，包含共轭物的组合物，其制备方法，以及用其组合物的共轭物治疗各种疾病的方法。
• SHIELDING COATING FOR SELECTIVE METALLIZATION
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：EP3293286A1

  公开（公告）日：2018-03-14

  Shielding coatings are applied to polymer substrates for selective metallization of the substrates. The shielding coatings include a primer component and a hydrophobic top coat. The primer is first applied to the polymer substrate followed by application of the top coat component. The shielding coating is then selectively etched to form an outline of a desired current pattern. A catalyst is applied to the patterned polymer substrate followed by electroless metal plating in the etched portions. The portions of the polymer substrate which contain the shielding coating inhibit electroless metal plating. The primers contain five-membered heterocyclic nitrogen compounds and the top coat contains hydrophobic alky organic compounds.

  屏蔽涂层适用于聚合物基底，用于基底的选择性金属化。屏蔽涂层包括底漆成分和疏水性面漆成分。首先将底漆涂抹在聚合物基材上，然后涂抹面漆成分。然后对屏蔽涂层进行选择性蚀刻，以形成所需的电流图案轮廓。将催化剂涂抹到图案化的聚合物基底上，然后在蚀刻部分进行无电解金属电镀。聚合物基板上含有屏蔽涂层的部分可抑制化学金属电镀。底漆含有五元杂环氮化合物，面漆含有疏水醇基有机化合物。
• US9850578B1
  申请人：——

  公开号：US9850578B1

  公开（公告）日：2017-12-26
• US9970114B2
  申请人：——

  公开号：US9970114B2

  公开（公告）日：2018-05-15