N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[4-(4-methyl-1-piperazinyl)-4-tetrahydropyranylethynyl]-6-quinazolinyl}acrylamide | 451494-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[4-(4-methyl-1-piperazinyl)-4-tetrahydropyranylethynyl]-6-quinazolinyl}acrylamide
• 英文别名: N-[4-(3-chloro-4-fluoroanilino)-7-[2-[4-(4-methylpiperazin-1-yl)oxan-4-yl]ethynyl]quinazolin-6-yl]prop-2-enamide
• CAS: 451494-18-1
• 化学式: C₂₉H₃₀ClFN₆O₂
• 分子量: 549.048
• InChiKey: UJDZAODZJUIGIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  82.6
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Quinazoline derivatives
  申请人：Kitano Yasunori

  公开号：US20070265260A1

  公开（公告）日：2007-11-15

  A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture thereof has a superior tyrosine-specific protein kinase inhibitory activity and is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of various cancers, psoriasis or diseases caused by arteriosclerosis, and the like.

  化合物(I)的配方或其药学上可接受的盐、水合物、溶剂合物、其光学活性化合物、其外消旋体混合物或其差向异构体混合物具有优越的酪氨酸特异性蛋白激酶抑制活性，并可用作药物制剂，特别是用作预防或治疗各种癌症、银屑病或动脉硬化引起的疾病等的药物。
• MOLECULAR CHAPERONE FUNCTION REGULATOR
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1792898A1

  公开（公告）日：2007-06-06

  According to the present invention, a molecular chaperone function regulator containing a quinazoline derivative represented by the following formula (I) wherein each symbol is as defined in Claims, or a pharmaceutically acceptable salt thereof, a hydrate or solvate thereof, an optically active form or racemate thereof or a diastereomer mixture thereof as an active ingredient can be provided.

  根据本发明，一种分子伴侣功能调节剂含有下式（I）所代表的喹唑啉衍生物 其中各符号如权利要求中定义，或其药学上可接受的盐、其水合物或溶液、其光学活性形式或外消旋物或其非对映异构体混合物作为活性成分。
• Molecular Chaperone Function Regulator
  申请人：Suzuki Tsuyoshi

  公开号：US20080200433A1

  公开（公告）日：2008-08-21

  According to the present invention, a molecular chaperone function regulator containing a quinazoline derivative represented by the following formula (I) wherein each symbol is as defined in Claims, or a pharmaceutically acceptable salt thereof, a hydrate or solvate thereof, an optically active form or racemate thereof or a diastereomer mixture thereof as an active ingredient can be provided.
• US7294629B2
  申请人：——

  公开号：US7294629B2

  公开（公告）日：2007-11-13