1-chloro-6-ethylisoquinoline | 630422-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-chloro-6-ethylisoquinoline
• CAS: 630422-58-1
• 化学式: C₁₁H₁₀ClN
• 分子量: 191.66
• InChiKey: PVNBVXYBOXNEOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE
  申请人：deLong Mitchell A.

  公开号：US20100280011A1

  公开（公告）日：2010-11-04

  Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.

  提供了既能抑制rho激酶又能抑制单胺转运体（MAT）的化合物，可用于改善疾病状态或病情。还提供了含有这些化合物的组合物。还提供了根据本发明给药的治疗疾病或病情的方法。其中一种疾病可能是青光眼，除了其他有益效果外，还可以显著降低眼内压（IOP）。
• DUAL-ACTION INHBITORS AND METHODS OF USING SAME
  申请人：deLong Mitchell A.

  公开号：US20120135984A1

  公开（公告）日：2012-05-31

  Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine transporters, such as NET or SERT, act in concert to improve the condition.

  提供了化合物、组合物和方法，用于治疗疾病和情况，其中激酶抑制剂，如rho激酶（ROCK），和一种或多种单胺转运体抑制剂，如NET或SERT，共同作用以改善病情。
• US8394826B2
  申请人：——

  公开号：US8394826B2

  公开（公告）日：2013-03-12
• [EN] HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010117977A1

  公开（公告）日：2010-10-14

  The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.