17-Methylene-estra-1,3,5(10),6,8(9)-pentaen-3-ol | 161062-05-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17-Methylene-estra-1,3,5(10),6,8(9)-pentaen-3-ol
• 英文别名: 17-METHYLENEESTRA-1,3,5,7,9-PENTAEN-3-OL；(13S,14R)-13-methyl-17-methylidene-12,14,15,16-tetrahydro-11H-cyclopenta[a]phenanthren-3-ol
• CAS: 161062-05-1
• 化学式: C₁₉H₂₀O
• 分子量: 264.367
• InChiKey: QEAGVIXEWSIGLU-RBUKOAKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Novel estrenes for inducing hypothalamic effects
  申请人：PHERIN CORPORATION

  公开号：EP0924219A2

  公开（公告）日：1999-06-23

  The invention relates to estrene steroids, which bind to neuroepithelial cells in the human vomeronasal organ. The steroids are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Figure (1) illustrates the synthesis of 1,3,5(10), 16-estratetraen-3-ol.

  本发明涉及与人类绒毛器官神经上皮细胞结合的雌烯类固醇。这种类固醇最好以药物组合物的形式给药，组合物中含有一种或多种药学上可接受的载体。图（1）说明了 1,3,5(10),16-雌甾-3-醇的合成过程。
• ESTRENE STEROIDS AS NEUROCHEMICAL INITIATORS OF CHANGE IN HUMAN HYPOTHALAMIC FUNCTION AND RELATED PHARMACEUTICAL COMPOSITIONS
  申请人：Pherin Pharmaceuticals, Inc.

  公开号：EP0715517B1

  公开（公告）日：2003-11-05
• NOVEL ESTRENES FOR INDUCING HYPOTHALAMIC EFFECTS
  申请人：PHERIN CORPORATION

  公开号：EP0783513A1

  公开（公告）日：1997-07-16
• EP0783513A4
  申请人：——

  公开号：EP0783513A4

  公开（公告）日：2000-03-08
• Items Containing A Human Pheromone Component
  申请人：Marenberg Barry J.

  公开号：US20100111896A1

  公开（公告）日：2010-05-06

  Food items, cosmetics and household items having a human pheromone component. Also disclosed are body washes, body splashes and body lotions that contain an incorporated human pheromone component or ingredient and methods for producing these products.