3-Piperidino-1,2,4-triazol | 18377-88-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Piperidino-1,2,4-triazol
• 英文别名: 1-(1H-[1,2,4]triazol-3-yl)-piperidine；1-(4H-1,2,4-triazol-3-yl)piperidine；1-(1H-1,2,4-triazol-5-yl)piperidine
• CAS: 18377-88-3
• 化学式: C₇H₁₂N₄
• mdl: MFCD20547464
• 分子量: 152.199
• InChiKey: COAPWPLCJMVVNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-Piperidin-1-yl-3H-[1,2,4]triazole-1,2-dicarboxylic acid diethyl ester 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以74%的产率得到3-Piperidino-1,2,4-triazol
  参考文献：
  名称：

  Cycloaddition of Synthetic Equivalent of Non-stabilized Aminonitrile Ylides: A New Route to Amino-substituted D2-Imidazolines and D3-1,2,4-Triazolines

  摘要：

  The N-unsubstituted nonstabilized azomethine ylides generated from the desilylation of N- [(trimethylsilyl)methyl]iminium triflates undergo successful cycloaddition to strongly polarized sulfonylimines and diethyl azodicarboxylate to produce the corresponding Delta (2)-imidazolines and Delta (3)-1,2,4-triazolines together with the initial cycloadducts. The initial cycloadducts are converted to the corresponding aminonitrile ylide cycloadducts. Thus the present process provides a new route to amino-substituted Delta (2)-imidazolines and Delta (3)-1,2,4-triazolines that are otherwise relatively inaccessible.

  DOI：

  10.3987/com-00-9121

文献信息

• 6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[D] Azepines as 5-Ht2c Receptro Agonists
  申请人：Allen John Gordon

  公开号：US20080207897A1

  公开（公告）日：2008-08-28

  The present invention provides 6-substituted 2,3,4,5-tetrahydro- 1 H-benzo[d]azepines of Formula (I) as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where R 6 is —C≡C—R 10 , —CH═CR 11 R 11′ , or —(C 0 -C 8 )alkyl-Ar 2 optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents and other substituents are as defined in the specification.

  本发明提供了式（I）的6-取代的2,3,4,5-四氢-1H-苯并[d]氮杂环化合物，作为选择性5-HT2C受体激动剂，用于治疗与5-HT2C相关的疾病，包括肥胖症、强迫症、抑郁症和焦虑症：其中R6为—C≡C—R10，—CH═CR11R11′，或—(C0-C8)烷基-Ar2，烷基上可选地带有1至6个氟取代基，其他取代基在规范中定义。
• 1,3,5-SUBSTITUTED 3-PIPERAZINE- OR 3-PIPERIDINE-1,2,4-TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Janssen Pharmaceuticals, Inc.

  公开号：EP2688874B1

  公开（公告）日：2015-03-04