(S,S)-6-(4-Amino-butyl)-1-[4-(methyl-phenyl-amino)-benzyl]-3-naphthalen-2-ylmethyl-piperazine-2,5-dione | 702689-46-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (S,S)-6-(4-Amino-butyl)-1-[4-(methyl-phenyl-amino)-benzyl]-3-naphthalen-2-ylmethyl-piperazine-2,5-dione
• 英文别名: (3S,6S)-6-(4-aminobutyl)-1-[[4-(N-methylanilino)phenyl]methyl]-3-(naphthalen-2-ylmethyl)piperazine-2,5-dione
• CAS: 702689-46-1
• 化学式: C₃₃H₃₆N₄O₂
• 分子量: 520.674
• InChiKey: YFMBEIORFFNWMI-CONSDPRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  78.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compounds and compositions for treating obesity
  申请人：Conde-Frieboes Waldemar Kilian

  公开号：US20070185128A1

  公开（公告）日：2007-08-09

  Described herein are novel and useful compounds of the general formula Compounds of this invention can advantageously exhibit melanocortin receptor agonist activity. New and useful compounds comprising such a chemical structure and methods of modulating melanocortin receptor activity in a subject (and promoting, inducing, and/or enhancing the treatment or prevention of related diseases) by administering such a compound or composition also are described.

  本文描述了一种新颖且有用的化合物，其一般公式为。本发明的化合物可以有利地表现为黑色素皮质素受体激动剂活性。还描述了包含这种化学结构的新型和有用的化合物，以及通过给予这种化合物或组合物来调节受体在受试者中的活性（并促进、诱导和/或增强相关疾病的治疗或预防）的方法。
• 2,5-DIKETOPIPERAZINES FOR THE TREATMENT OF OBESITY
  申请人：NOVO NORDISK A/S

  公开号：EP1572669A2

  公开（公告）日：2005-09-14
• [EN] COMPOUNDS FOR USE IN TREATING OBESITY<br/>[FR] COMPOSES DESTINES AU TRAITEMENT DE L'OBESITE
  申请人：NOVO NORDISK AS

  公开号：WO2004048345A2

  公开（公告）日：2004-06-10

  The present invention relates to novel compounds of the general formula (I) as well as any optical or geometric isomer or tautomer form thereof, or a pharmaceutically acceptable salt thereof, as agonists of melanocortin receptors, such as agonists of the MC4 receptor. The compounds may for instance be used in the treatment of obesity.