10,13-dimethyl-17-[2-(6-sulfanylidene-3H-purin-9-yl)acetyl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | 17392-79-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 10,13-dimethyl-17-[2-(6-sulfanylidene-3H-purin-9-yl)acetyl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 17392-79-9
• 化学式: C₂₆H₃₂N₄O₂S
• 分子量: 464.6
• InChiKey: UWSZBXUQILDRMN-UHFFFAOYSA-N

物化性质

• 沸点：
  692.6±65.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO: 10mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  78.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Methods for treating hair loss disorders
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US10994157B2

  公开（公告）日：2021-05-04

  The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.

  本发明提供了通过施用 Janus 激酶/信号转导子和转录激活子抑制剂治疗受试者脱发疾病的方法。
• ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS
  申请人：TUDAG TU Dresden Aktiengesellschaft

  公开号：EP3578981B1

  公开（公告）日：2021-10-27
• Methods for Treating Hair Loss Disorders
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US20140065153A1

  公开（公告）日：2014-03-06

  The invention provides for methods for treating a hair loss disorder in a subject by administering a JAK/STAT inhibitor.
• METHODS FOR TREATING HAIR LOSS DISORDERS
  申请人：The Trustees of Columbia University in The City of New York

  公开号：US20160058764A1

  公开（公告）日：2016-03-03

  The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
• US9198911B2
  申请人：——

  公开号：US9198911B2

  公开（公告）日：2015-12-01