4-N,6-N-bis(4-bromophenyl)-1-methylpyrazolo[3,4-d]pyrimidine-4,6-diamine | 101606-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 4-N,6-N-bis(4-bromophenyl)-1-methylpyrazolo[3,4-d]pyrimidine-4,6-diamine
• 英文别名: NSC11667；N⁴,N⁶-bis-(4-bromo-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diyldiamine；N⁴,N⁶-Bis-(4-brom-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4,6-diyldiamin
• CAS: 101606-33-1
• 化学式: C₁₈H₁₄Br₂N₆
• 分子量: 474.157
• InChiKey: PWZSMHFUFVPPLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  67.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SMALL MOLECULES FOR RESTORING FUNCTION TO P53 CANCER MUTANTS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150307519A1

  公开（公告）日：2015-10-29

  Embodiments of the present provide methods of inducing p53 SRMMP-dependent cancer cell cytotoxicity. Such methods involve the steps of exposing a cancer cell that comprises a p53 SRMMP to an amount of a chemical compound sufficient to induce p53 SRMMP-dependent cancer cell cytotoxicity. In one embodiment, the present invention provides a method of treating cancer by determining the presence of a p53 mutation, and administering a therapeutically effective dosage of a composition comprising one or more promoting compounds.