2-formyl-1-(3,4-methylenedioxyphenyl)-1-pentene | 51021-63-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醛
• 英文名称: 2-formyl-1-(3,4-methylenedioxyphenyl)-1-pentene
• 英文别名: (2E)-2-(1,3-benzodioxol-5-ylmethylidene)pentanal
• CAS: 51021-63-7
• 化学式: C₁₃H₁₄O₃
• 分子量: 218.252
• InChiKey: PCHDAKPAVDLTPI-IZZDOVSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Aromatic amides as potentiators of bioefficacy of anti-infective drugs
  申请人：Koul Surrinder

  公开号：US20070004645A1

  公开（公告）日：2007-01-04

  The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

  本发明涉及芳香取代的戊二烯酸酰胺及其在芳香酰胺的特定量的组合中的使用，即4-烷基-5-(取代苯基)-2(E),4(E)-戊二烯酸酰胺，其几何异构体或其二氢或四氢衍生物，以及一种抗感染药物，有助于增强抗感染药物的生物功效。本发明的组合物在治疗某些感染和疾病方面非常有用，可以在抑制微生物菌株生长所需的抗感染剂浓度较低的情况下发挥作用，并且还可以在减少微生物的抗药性方面发挥作用。
• AROMATIC AMIDES AS POTENTIATORS OF BIOEFFICACY OF ANTI-INFECTIVE DRUGS
  申请人：Council Of Scientific and Industrial Research

  公开号：US20140073595A1

  公开（公告）日：2014-03-13

  The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

  本发明涉及芳香基取代的戊二烯酸酰胺及其在特定量的芳香酰胺，即4-烷基-5-（取代苯基）-2（E），4（E）-戊二烯酸酰胺，其几何异构体或其二氢或四氢衍生物和抗感染药物的组合物中的使用，有助于增强抗感染药物的生物功效。本发明的组合物对于治疗某些感染和疾病有用，可在抑制微生物菌株生长所需的抗感染剂浓度较低的情况下发挥作用，并且还可在减少微生物的耐药性方面应用。
• Indene compounds
  申请人：Taiyo Pharmaceutical Industry Co., Ltd.

  公开号：EP0235345A1

  公开（公告）日：1987-09-09

  The invention provides an indene compound represented by the following general formula (I): wherein R1 means a lower alkyl group, R2 and R3 denote a lower alkyl group individually or an alkylenedioxy group in combination, and R4 and R5 mean individually a substituted or unsubstituted lower alkyl or aryl group or in combination a substituted or unsubstituted piperidino, piperazinyl or homopiperazinyl group together with the adjacent nitrogen atom, with a proviso that not both R4 and R5 are a methyl group at the same time.

  本发明提供了一种由以下通式（I）表示的茚类化合物：其中 R1 表示低级烷基，R2 和 R3 单独表示低级烷基或组合表示亚烷基二氧基，R4 和 R5 单独表示取代或未取代的低级烷基或芳基，或组合表示取代或未取代的哌啶基、哌嗪基或均哌嗪基以及相邻的氮原子，但 R4 和 R5 不能同时为甲基。
• US4762927A
  申请人：——

  公开号：US4762927A

  公开（公告）日：1988-08-09
• US4876345A
  申请人：——

  公开号：US4876345A

  公开（公告）日：1989-10-24