(4-Methylthiophen-3-yl)methanamine | 104163-38-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (4-Methylthiophen-3-yl)methanamine
• CAS: 104163-38-4
• 化学式: C₆H₉NS
• mdl: MFCD23774679
• 分子量: 127.21
• InChiKey: NUOZTFAOKMVNAU-UHFFFAOYSA-N

物化性质

• 沸点：
  208.8±25.0 °C(Predicted)
• 密度：
  1.104±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA
  申请人：Northwestern University

  公开号：US20180098952A1

  公开（公告）日：2018-04-12

  Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection by Toxoplasma gondii and toxoplasmosis and for treating infection by Plasmodium falciparum and malaria. The compounds disclosed herein are observed to selectively inactivate Toxoplasma gondii ornithine aminotransferase (TgOAT) relative to human OAT and relative to human γ-aminobutyric aminotransferase (GABA-AT).

  揭示了一种治疗具有选择性灭活裂殖孢子虫的鸟氨基转移酶的化合物、方法和组合物。具体来说，这些方法、化合物可用于治疗弓形虫和弓形虫病感染，以及治疗疟原虫和疟疾感染。本文披露的化合物被观察到相对于人类鸟氨基转移酶和人类γ-氨基丁酸氨基转移酶（GABA-AT）具有选择性地灭活弓形虫鸟氨基转移酶（TgOAT）。
• Purine derivatives
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0178178A2

  公开（公告）日：1986-04-16

  Novel purine derivatives, particularly novel guanines and hypoxanthines, are described as agents for treating autoimmune diseases. The compounds have the following formula (I): or a pharmaceutically acceptable acid addition or base salt thereof; wherein: Rl is OH or SH; R2 is (i) hydrogen or (ii) NHR in which R is hydrogen or CORe in which R6 is alkyl of one to four carbon atoms, aryl or arylalkyl; R3 is hydrogen, hydroxyl, mercapto, bromide or NHR in which R is hydrogen or COR6; n is zero or one, m is zero or one or two or three, with the proviso that m or n is at least one; R4 and Rs are each, independently, hydrogen, alkyl of from one to four carbon atoms, aryl, arylalkyl, cycloalkyl of from three to six carbon atoms or hydroxyalkyl of from one to four carbon atoms; and Ar is heteroaryl or heteroaryl substituted by (i) alkyl of from one to four carbon atoms, (ii) alkoxy of from one to four carbon atoms, or (iii) -C = C-C = C- attached to adjacent carbon atoms of the heteroaryl to form a benzo radical, or (iv) halogen; excluding the compound wherein R1 is OH, R2 is amino, R3 is hydrogen, n is zero, m is one, and Ar is 2-furanyl.

  新型嘌呤衍生物，特别是新型鸟嘌呤和次黄嘌呤，被描述为治疗自身免疫性疾病的药物。这些化合物具有下式 (I)： 或其药学上可接受的酸加成盐或碱式盐； 其中Rl 是 OH 或 SH； R2是(i)氢或(ii)NHR，其中R是氢或CORe，其中R6是一至四个碳原子的烷基、芳基或芳烷基； R3 是氢、羟基、巯基、溴化物或 NHR，其中 R 是氢或 COR6； n 为 0 或 1，m 为 0 或 1 或 2 或 3，但 m 或 n 至少为 1； R4 和 Rs 各自独立地为氢、一至四个碳原子的烷基、芳基、芳烷基、三至六个碳原子的环烷基或一至四个碳原子的羟烷基；以及 Ar 是杂芳基或被以下物质取代的杂芳基：(i) 1 至 4 个碳原子的烷基，(ii) 1 至 4 个碳原子的烷氧基，或 (iii) 连接到杂芳基相邻碳原子上形成苯偶氮基的-C = C-C = C-，或 (iv) 卤素；不包括 R1 为 OH、R2 为氨基、R3 为氢、n 为零、m 为 1 且 Ar 为 2-呋喃基的化合物。
• BIARYL COMPOUNDS AS SERINE PROTEASE INHIBITORS
  申请人：BIOCRYST PHARMACEUTICALS, INC.

  公开号：EP1383731B1

  公开（公告）日：2009-08-05
• US4772606A
  申请人：——

  公开号：US4772606A

  公开（公告）日：1988-09-20
• US4952693A
  申请人：——

  公开号：US4952693A

  公开（公告）日：1990-08-28