2-(N-methylamino)-3,4-dihydroquinazoline hydriodide | 75191-74-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(N-methylamino)-3,4-dihydroquinazoline hydriodide
• 英文别名: N-methyl-3,4-dihydro-1H-quinazolin-2-imine;hydroiodide
• CAS: 75191-74-1
• 化学式: C₉H₁₁N₃*HI
• 分子量: 289.119
• InChiKey: QHVKVAIVRRPYOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  36.4
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,4-dihydro-1H-quinazoline-2-thione 以 乙醇 、 水 为溶剂， 反应 4.75h， 生成 2-(N-methylamino)-3,4-dihydroquinazoline hydriodide
  参考文献：
  名称：

  Synthesis and adrenergic blocking effects of 2-(alkylamino)-3,4-dihydroquinazolines

  摘要：

  Based on the known biological activity of a variety of guanidine-containing agents, several N-substituted 3,4-dihydroquinazolines were synthesized. These compounds can be considered to be rigid analogues of phenylguanidines. In anesthetized rats the compounds decreased blood pressure and were antagonists of the pressor response to norepinephrine.

  DOI：

  10.1021/jm00185a026

文献信息

• GROSSO J. A.; NICHOLS D. E.; NICHOLS M. B.; YIM G. K. W., J. MED. CHEM., 1980, 23, NO 11, 1261-1264
  作者：GROSSO J. A.、 NICHOLS D. E.、 NICHOLS M. B.、 YIM G. K. W.

  DOI：——

  日期：——
• Synthesis and adrenergic blocking effects of 2-(alkylamino)-3,4-dihydroquinazolines
  作者：John A. Grosso、David E. Nichols、Maxine B. Nichols、George K. W. Yim

  DOI：10.1021/jm00185a026

  日期：1980.11

  Based on the known biological activity of a variety of guanidine-containing agents, several N-substituted 3,4-dihydroquinazolines were synthesized. These compounds can be considered to be rigid analogues of phenylguanidines. In anesthetized rats the compounds decreased blood pressure and were antagonists of the pressor response to norepinephrine.