(3R,5R)-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-8-[(3-chloro-2-methylphenyl)methyl]-3-(2,4-dichlorophenyl)-2,8-diazaspiro[4.5]decane-1,7-dione | 873577-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R,5R)-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-8-[(3-chloro-2-methylphenyl)methyl]-3-(2,4-dichlorophenyl)-2,8-diazaspiro[4.5]decane-1,7-dione
• CAS: 873577-61-8
• 化学式: C₃₀H₃₉Cl₃N₂O₃Si
• 分子量: 610.096
• InChiKey: INMWJBLEDKEBFF-PDDLMNHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.06
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3R,5R)-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-8-[(3-chloro-2-methylphenyl)methyl]-3-(2,4-dichlorophenyl)-2,8-diazaspiro[4.5]decane-1,7-dione 在 jones reagent 作用下， 以 丙酮 为溶剂， 以80%的产率得到
  参考文献：
  名称：

  Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists

  摘要：

  The synthesis of racemic and non-racemic spirocyclic lactams that display high binding affinity toward CCR4 is described. Two distinct series of spirocycles were prepared from the common intermediate 9. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.139
• 作为产物：
  描述：

  (3R)-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-3-(2,4-dichlorophenyl)-2-azaspiro[4.4]non-7-en-1-one 在 三乙酰氧基硼氢化钠 、 碳酸氢钠 、 臭氧 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 生成 (3R,5R)-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-8-[(3-chloro-2-methylphenyl)methyl]-3-(2,4-dichlorophenyl)-2,8-diazaspiro[4.5]decane-1,7-dione
  参考文献：
  名称：

  Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists

  摘要：

  The synthesis of racemic and non-racemic spirocyclic lactams that display high binding affinity toward CCR4 is described. Two distinct series of spirocycles were prepared from the common intermediate 9. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.139

文献信息

• Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists
  作者：Joshua D. Hansen、Bradley J. Newhouse、Shelley Allen、Aaron Anderson、Todd Eary、Justin Schiro、John Gaudino、Ellen Laird、Andrew C. Allen、David Chantry、Christine Eberhardt、Laurence E. Burgess

  DOI：10.1016/j.tetlet.2005.10.139

  日期：2006.1

  The synthesis of racemic and non-racemic spirocyclic lactams that display high binding affinity toward CCR4 is described. Two distinct series of spirocycles were prepared from the common intermediate 9. (c) 2005 Elsevier Ltd. All rights reserved.