2-(4-(dimethylamino)phenyl)-3-iodo-5,6-dihydro-4H-cyclopenta[b]furan-4-ol | 1381891-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-(4-(dimethylamino)phenyl)-3-iodo-5,6-dihydro-4H-cyclopenta[b]furan-4-ol
• CAS: 1381891-00-4
• 化学式: C₁₅H₁₆INO₂
• 分子量: 369.202
• InChiKey: SHNXTXBUCNSFIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  36.61
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-(4-(dimethylamino)phenyl)-3-iodo-5,6-dihydro-4H-cyclopenta[b]furan-4-ol 、 3-氟-4-甲氧基苯硼酸 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 以52%的产率得到2-(4-(dimethylamino)phenyl)-3-(3-fluoro-4-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]furan-4-ol
  参考文献：
  名称：

  Solution-Phase Synthesis of a Highly Substituted Furan Library

  摘要：

  A library of furans has been synthesized by iodocyclization and further diversified by palladium-catalyzed coupling processes. The key intermediate 3-iodofurans have been prepared by the electrophilic iodocyclization of 2-iodo-2-alken-1-ones in the presence of various nucleophiles in good to excellent yields under mild reaction conditions. These 3-iodofurans are the key components for library generation through subsequent elaboration by palladium-catalyzed processes, such as Suzuki-Miyaura, Sonagashira, Heck, aminocarbonylation, and carboalkoxylation chemistry to afford a diverse set of 2,3,4,5-tetrasubstituted furans.

  DOI：

  10.1021/co300040q
• 作为产物：
  描述：

  2-碘-2-环戊烯-1-酮 在 copper(l) iodide 、 bis(triphenylphosphine)palladium(II)-chloride 、 水 、 碘 、 碳酸氢钠 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 0.5h， 生成 2-(4-(dimethylamino)phenyl)-3-iodo-5,6-dihydro-4H-cyclopenta[b]furan-4-ol
  参考文献：
  名称：

  Solution-Phase Synthesis of a Highly Substituted Furan Library

  摘要：

  A library of furans has been synthesized by iodocyclization and further diversified by palladium-catalyzed coupling processes. The key intermediate 3-iodofurans have been prepared by the electrophilic iodocyclization of 2-iodo-2-alken-1-ones in the presence of various nucleophiles in good to excellent yields under mild reaction conditions. These 3-iodofurans are the key components for library generation through subsequent elaboration by palladium-catalyzed processes, such as Suzuki-Miyaura, Sonagashira, Heck, aminocarbonylation, and carboalkoxylation chemistry to afford a diverse set of 2,3,4,5-tetrasubstituted furans.

  DOI：

  10.1021/co300040q