3,7,8,10-Tetramethylisoalloxazin-5-oxid | 36995-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 3,7,8,10-Tetramethylisoalloxazin-5-oxid
• 英文别名: 3-Methyl-lumiflavin-5-oxid；3,7,8,10-tetramethyl-5-oxy-10H-benzo[g]pteridine-2,4-dione；3,7,8,10-Tetramethyl-5-oxidobenzo[g]pteridin-5-ium-2,4-dione
• CAS: 36995-94-5
• 化学式: C₁₄H₁₄N₄O₃
• 分子量: 286.29
• InChiKey: NCSZUUQQGAAQAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• FLAVIN N-OXIDES: NEW ANTI-CANCER AGENTS AND PATHOGEN ERADICATION AGENTS
  申请人：Platz Matthew S.

  公开号：US20080206736A1

  公开（公告）日：2008-08-28

  Compounds comprising flavin N-oxides for treatments of solid tumors, non-solid tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods of treating patients having solid type cancers comprising administering a therapeutically effective amount of a flavin N-oxide to a subject in need of treatment and exposing the flavin N-oxide to an activator such that activation of the flavin N-oxide results in damage to the DNA in the cancer cells without substantial damage to the DNA of normal cells are also provided. Methods of using a flavin N-oxide as part of a combination therapy with chemotherapy, radiation therapy, or both are also provided. Methods of reducing pathogenic bacterial or viral contamination in a composition comprising a) mixing the composition with an efficacious amount of a flavin N-oxide and b) exposing the mixture of the composition and the flavin N-oxide to an activator for a period of time sufficient to activate the flavin N-oxide such that the flavin N-oxide reduces the contamination in the composition are also provided. Preferably, the composition is a blood product selected from plasma, platelets, and red blood cells and the activator is an enzyme.
• US7235392B2
  申请人：——

  公开号：US7235392B2

  公开（公告）日：2007-06-26