5-({5-[N-(6-carboxynaphthyl)carbamoyl]-3-[(4-methylphenyl)carbonylamino]-phenyl}carbonylamino)naphthalene-2-carboxylic acid | 325981-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-({5-[N-(6-carboxynaphthyl)carbamoyl]-3-[(4-methylphenyl)carbonylamino]-phenyl}carbonylamino)naphthalene-2-carboxylic acid
• 英文别名: 5-[[3-[(6-Carboxynaphthalen-1-yl)carbamoyl]-5-[(4-methylbenzoyl)amino]benzoyl]amino]naphthalene-2-carboxylic acid
• CAS: 325981-25-7
• 化学式: C₃₈H₂₇N₃O₇
• 分子量: 637.648
• InChiKey: TVUAPQULUTYIQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  48
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  162
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• NAPHTHYLSULFONIC ACIDS AND RELATED COMPOUNDS AS GLUCOSE UPTAKE AGONISTS
  申请人：TELIK, INC.

  公开号：EP1200396A1

  公开（公告）日：2002-05-02
• US6653321B1
  申请人：——

  公开号：US6653321B1

  公开（公告）日：2003-11-25
• [EN] NOVEL NAPHTHYLSULFONIC ACIDS AND RELATED COMPOUNDS AS GLUCOSE UPTAKE AGONISTS<br/>[FR] NOUVEAUX ACIDES NAPHTYLSULFONIQUES ET COMPOSES APPARENTES UTILISES COMME AGONISTES DE CAPTAGE DU GLUCOSE
  申请人：TELIK INC

  公开号：WO2001012591A1

  公开（公告）日：2001-02-22

  Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds are provided. Compounds of formula (1) where: R?1 and R2¿ are, independently, hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, R3 is a substituent on the B ring; and is -SO¿2OR?6, -C(O)OR6, -SO2NR62-C(O)NR62 or tetrazolyl; the linker -WY- between the naphthyl and phenyl intersects the A ring of the naphthyl and is, independently, -C(O)NR?7-, -NR7¿C(O)-, -C(O)O-, -OC(O)-, -CH=CH-, -NR7CH2-, -CH2NR?7-, -NR7C(O)NR7- -NR7¿C(O)O-, -OC(O)NR?7-, -NR7SO¿2O-, -OSO2NR7-, -OC(O)O-, -SO¿2?NR?7-, -NR7SO¿2-, -OSO2-, or -SO2O-; each R?6 and R7¿ is, independently, hydrogen or lower alkyl; optionally in the form of single stereoisomers or mixtures of stereoisomers, or the pharmaceutically acceptable salts thereof; are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.