2-(3,4-dihydroxybenzylideneamino)pyridin-3-ol | 1246614-27-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(3,4-dihydroxybenzylideneamino)pyridin-3-ol
• 英文别名: 4-[(3-Hydroxypyridin-2-yl)iminomethyl]benzene-1,2-diol
• CAS: 1246614-27-6
• 化学式: C₁₂H₁₀N₂O₃
• 分子量: 230.223
• InChiKey: XZJDEXPIKZVVFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-3-羟基吡啶 、 3,4-二羟基苯甲醛 以 乙醇 为溶剂， 以85%的产率得到2-(3,4-dihydroxybenzylideneamino)pyridin-3-ol
  参考文献：
  名称：

  Synthesis, solvatochromaticity and bioactivities of some transition metal complexes with 2-(R-benzylideneamino)-pyridin-3-ol Schiff base derivatives

  摘要：

  New four Schiff bases are prepared by condensation of 2-amino-pyridin-3-ol with 3, 4-dihydroxy-benzaldehyde (I), 2-hydroxybenzaldehyde (II), 5-bromo-2-hydroxybenzaldehyde (III), and 4-dimethylaminobenzaldehyde (IV). The structures of these compounds are characterized based on elemental analyses (C, H, N), IR and H-1 NMR. Also, the electronic absorption spectra are recorded in organic solvents of different polarity. The solvents are selected to be covered a wide range of parameters (refractive index, dielectric constant and hydrogen bonding capacity). The UV-vis absorption spectra of Schiff base compounds are investigated in aqueous buffer solutions of varying pH and utilized for the determination of ionization constant, pK(a) and activation free energy. Delta G* of the ionization process. The biological activity against bacterial species and fungi as microorganisms representing different microbial categories such as (two Gram-negative bacteria, Eschericha coli and Agrobacterium sp.),three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtlus and Bacillus megatherium), yeast (Candida albicans), and fungi (Aspergillus niger) were studied. (C) 2010 Published by Elsevier B.V.

  DOI：

  10.1016/j.saa.2010.03.026