4-amino-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine | 865365-87-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 4-amino-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine
• 英文别名: 5-ethynyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• CAS: 865365-87-3
• 化学式: C₈H₆N₄
• 分子量: 158.162
• InChiKey: NASVPSCCMRQGPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE
  申请人：Institute of Organic Chemistry and Biochemistry ASCR, V.V.I.

  公开号：EP3936514A1

  公开（公告）日：2022-01-12

  The present disclosure relates to 3'3' cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

  本公开涉及一般式（J）的3'3'环磷酸二核苷酸，其药用盐，其药物组合物以及所述物质与其他药物或药品的组合物。该公开还涉及利用所述化合物治疗或预防可通过STING蛋白调节改变的疾病或症状，如癌症或病毒性、过敏性和炎症性疾病。此外，这些物质可用作疫苗的辅助剂。
• Methods for preparing 7-(2'-substituted-beta-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
  申请人：Roberts D. Christopher

  公开号：US20050215510A1

  公开（公告）日：2005-09-29

  Disclosed are methods and intermediates for the preparation of 7-(2′-R 1 -substituted-β-D-ribofuranosyl)-4-amino-5-(optionally substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine compounds. These compounds are useful in treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.

  本发明涉及制备7-(2'-R1-取代的β-D-核糖呋喃基)-4-氨基-5-(可选择取代的乙炔基)-吡咯并[2,3-d]嘧啶类化合物的方法和中间体。这些化合物可用于治疗由黄病毒科病毒引起的病毒感染，例如丙型肝炎病毒。
• METHODS FOR PREPARING 7-(2 -SUBSTITUTED-s-D-RIBOFURANO SYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO 2,3-D|PYRIMIDINE DERIVATIVES
  申请人：GENELABS TECHNOLOGIES, INC.

  公开号：EP1682564A1

  公开（公告）日：2006-07-26
• US7169918B2
  申请人：——

  公开号：US7169918B2

  公开（公告）日：2007-01-30
• [EN] METHODS FOR PREPARING 7-(2'-SUBSTITUTED-ß-D-RIBOFURANOSYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES<br/>[FR] PROCEDES DE PREPARATION DE DERIVES 7-(2'- DOLLAR G(B)-D-RIBOFURANOSYL SUBSTITUE)-4-(NR<2>R<3>)-5-(ETHYN-1-YL SUBSTITUE)-PYRROLO[2,3-D]PYRIMIDINE
  申请人：GENELABS TECH INC

  公开号：WO2005044835A1

  公开（公告）日：2005-05-19

  Disclosed are methods and intermediates for the preparation of 7-(2'-R1-substituted-ß-D-ribofuranosyl)-4-amino-5-(optionally substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine compounds. These compounds are useful in treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.