4-Amino-6-chlor-1-isopropyl-pyrazolo<3.4-d>pyrimidin | 21254-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 4-Amino-6-chlor-1-isopropyl-pyrazolo<3.4-d>pyrimidin
• 英文别名: 6-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine；6-Chloro-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
• CAS: 21254-20-6
• 化学式: C₈H₁₀ClN₅
• 分子量: 211.654
• InChiKey: ILOMYTPLLGSQOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• DERIVATIVES OF GYLCERO-MANNO-HEPTOSE ADP FOR USE IN MODULATING IMMUNE RESPONSE
  申请人：Shanghai Yao Yuan Biotechnology Co., Ltd.

  公开号：US20220177510A1

  公开（公告）日：2022-06-09

  The disclosure provides compounds, compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A 1 , A 2 , L 1 , L 2 , L 3 , Z 1 , Z 2 , W 1 , W 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein.