2-morpholin-4-yl-2-pyridin-3-yl-pentanedinitrile | 36740-11-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-morpholin-4-yl-2-pyridin-3-yl-pentanedinitrile
• 英文别名: γ-Cyano-γ-morpholin-γ(3-pyridyl)butyronitril；2-(4-Morpholinyl)-2-(3-pyridinyl)pentanedinitrile；2-morpholin-4-yl-2-pyridin-3-ylpentanedinitrile
• CAS: 36740-11-1
• 化学式: C₁₄H₁₆N₄O
• 分子量: 256.307
• InChiKey: URBHBAWXICYFLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吗啉-4-基(吡啶-3-基)乙腈 在 氢氧化钾 作用下， 以 甲醇 、 叔丁醇 为溶剂， 生成 2-morpholin-4-yl-2-pyridin-3-yl-pentanedinitrile
  参考文献：
  名称：

  Synthesis of myosmine and nornicotine, using an acylcarbanion equivalent as an intermediate

  摘要：

  DOI：

  10.1021/jo00799a038

文献信息

• Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinones
  申请人：Sterling Drug Inc.

  公开号：US04486431A1

  公开（公告）日：1984-12-04

  4,5-Dihydro-4-R-6-(4-pyridinyl)-3(2H)-pyridazinone (IA) or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen or methyl, is shown as the active component in cardiotonic composition and method for increasing cardiac contractility in a patient requiring such treatment. Also shown is the preparation of IA by reacting a lower-alkyl 2-R-4-(BN)-4-cyano-4-(4-pyridinyl)butanoate with hydrazine, where R is hydrogen or methyl, and BN is 4-morpholinyl, 1-piperidinyl or 1-pyrrolidinyl.

  4,5-二氢-4-R-6-(4-吡啶基)-3(2H)-吡啶嗪酮(IA)或其药学上可接受的酸加成盐，其中R为氢或甲基，被证明是心脏强心剂组合物和增加需要此类治疗的患者心脏收缩力的方法中的活性成分。还展示了通过将较低烷基2-R-4-(BN)-4-氰基-4-(4-吡啶基)丁酸酯与肼反应制备IA的方法，其中R为氢或甲基，BN为4-吗啡啉基，1-哌啶基或1-吡咯烷基。
• 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a
  申请人：Sterling Drug Inc.

  公开号：US04337253A1

  公开（公告）日：1982-06-29

  2-R-4,5-dihydro-4-R'-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as cardiotonics, where R is lower-alkyl or lower-hydroxyalkyl, R' is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, are prepared by reacting 4-oxo-4-PY-2-R'-butanenitrile with an N-R-hydrazine salt of a strong inorganic acid or organic sulfonic acid or by reacting a lower-alkyl 4-oxo-4-PY-2-R'-butanoate or lower-alkyl 4-(BN)-4-cyano-4-PY-2-R'-butanoate with N-R-hydrazine where BN is 4-morpholinyl, 1-piperidinyl or 1-pyrrolidinyl. Also shown are: (a) cardiotonic compositions and a method for increasing cardiac contractility using said compounds or salts where R is lower-alkyl (b) the use of I as intermediates in preparing the corresponding 2-R-4-R'-6-PY-3(2H)-pyridazinones; and, (c) the preparation of said lower-alkyl 4-(BN)-4-cyano-4-PY-2-R'-butanoates.

  2-R-4,5-二氢-4-R'-6-PY-3(2H)-吡啶嗪酮（I）或其盐，可用作心脏强心剂，其中R为较低的烷基或较低的羟基烷基，R'为氢或较低的烷基，PY为4-或3-吡啶基或带有一或两个较低烷基取代基的4-或3-吡啶基，通过将4-氧代-4-PY-2-R'-丁腈与强无机酸或有机磺酸的N-R-腙盐反应或通过将较低烷基4-氧代-4-PY-2-R'-丁酸酯或较低烷基4-(BN)-4-氰基-4-PY-2-R'-丁酸酯与N-R-腙反应制备。还显示了：（a）心脏强心剂组合物和使用所述化合物或盐增加心脏收缩力的方法，其中R为较低的烷基；（b）将I用作制备相应的2-R-4-R'-6-PY-3(2H)-吡啶嗪酮的中间体；以及（c）制备所述较低烷基4-(BN)-4-氰基-4-PY-2-R'-丁酸酯。
• US4337253A
  申请人：——

  公开号：US4337253A

  公开（公告）日：1982-06-29
• US4486431A
  申请人：——

  公开号：US4486431A

  公开（公告）日：1984-12-04
• Synthesis of myosmine and nornicotine, using an acylcarbanion equivalent as an intermediate
  作者：Edward. Leete、Miles R. Chedekel、George B. Bodem

  DOI：10.1021/jo00799a038

  日期：1972.7.29