3-(Benzothiazol-2-ylsulfanyl)-2-(benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-2-carboxylic acid isopropyl ester | 657411-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 3-(Benzothiazol-2-ylsulfanyl)-2-(benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-2-carboxylic acid isopropyl ester
• 英文别名: Propan-2-yl 3-(1,3-benzothiazol-2-ylsulfanyl)-2-(1,3-benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-oxofuran-2-carboxylate
• CAS: 657411-22-8
• 化学式: C₂₃H₁₈N₂O₅S₄
• 分子量: 530.67
• InChiKey: DZPFXVSVSSZWMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  206
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Furanone derivatives
  申请人：——

  公开号：US20040029812A1

  公开（公告）日：2004-02-12

  The invention relates to a method of treating with furanone derivatives and the phmaceutically acceptable salts therof, one or more conditions of the skin, in particular regulating skin condition, regulating signs of skin aging, treating a number of conditions suchas contact dermatitis, skin irritation, rosacea, acne, psoriasis, and preventing and protecting skin tissue against age-related damage or damage resulting from insults such as harmful (UV) radiation or environmental pollution, stress and fatigue.

  该发明涉及一种利用呋喃酮衍生物及其药用盐治疗皮肤的方法，特别是调节皮肤状况，调节皮肤衰老迹象，治疗诸如接触性皮炎、皮肤刺激、酒渣鼻、痤疮、牛皮癣等多种疾病，以及预防和保护皮肤组织免受与年龄相关的损伤或因有害（紫外线）辐射、环境污染、压力和疲劳等因素导致的损害。
• FURANONE DERIVATIVES
  申请人：Galileo Pharmaceuticals, Inc.

  公开号：EP1660080A1

  公开（公告）日：2006-05-31
• US7985771B2
  申请人：——

  公开号：US7985771B2

  公开（公告）日：2011-07-26
• [EN] FURANONE DERIVATIVES<br/>[FR] DERIVES DE FURANONE
  申请人：GALILEO PHARMACEUTICALS INC

  公开号：WO2005016340A1

  公开（公告）日：2005-02-24

  The invention relates to a method of treating with furanone derivatives and the pharmaceutically acceptable salts thereof, one or more conditions of the skin, in particular regulating skin condition, regulating signs of skin aging, treating a number of conditions such as contact dermatitis, skin irritation, rosacea, acne, psoriasis, and preventing and protecting skin tissue against age-related damage or damage resulting from insults such as harmful (UV) radiation or environmental pollution, stress and fatigue.