1-((3-bromophenyl)(dimethylamino)methyl) naphthalen-2-ol | 1219978-21-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-((3-bromophenyl)(dimethylamino)methyl) naphthalen-2-ol
• 英文别名: 1-[(3-Bromophenyl)-(dimethylamino)methyl]naphthalen-2-ol；1-[(3-bromophenyl)-(dimethylamino)methyl]naphthalen-2-ol
• CAS: 1219978-21-8
• 化学式: C₁₉H₁₈BrNO
• 分子量: 356.262
• InChiKey: PVQHYLRXEFKWRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  间溴苯甲醛 、 二甲胺 、 2-萘酚 在 nanoparticle Fe₃O₄ 作用下， 反应 1.5h， 以90%的产率得到1-((3-bromophenyl)(dimethylamino)methyl) naphthalen-2-ol
  参考文献：
  名称：

  Solventless Synthesis of 1-(α-aminoalkyl) Naphthols, Betti Bases, Catalyzed by Nanoparticle Fe₃O₄ at Room Temperature

  摘要：

  A series of 1-(alpha-aminoalkyl) naphthols were synthesized expeditiously in good yields and selectivity from 2-naphthol, alkylamines and aldehydes in the presence of nanoparticle Fe3O4 at room temperature in solvent-free conditions.

  DOI：

  10.1080/15533174.2012.762381

文献信息

• Non-ionic surfactant catalyzed synthesis of Betti base in water
  作者：Atul Kumar、Maneesh Kumar Gupta、Mukesh Kumar

  DOI：10.1016/j.tetlet.2010.01.056

  日期：2010.3

  We have developed an efficient non-ionic surfactant (Triton X-100) catalyzed multicomponent synthesis of Betti base from secondary amine, aromatic aldehydes, and beta-naphthol using Mannich-type reaction in water. Lewis and Bronsted acid catalysts, ionic and non-ionic surfactant have been screened for the reaction. Non-ionic surfactant (Triton X-100) gave the best results and the reaction proceeds through the imine formation, which is stabilized by colloidal dispersion and undergoes nucleophilic addition to afford the corresponding N,N-dialkylated Betti base in excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.
• Solventless Synthesis of 1-(α-aminoalkyl) Naphthols, Betti Bases, Catalyzed by Nanoparticle Fe₃O₄ at Room Temperature
  作者：Fatemeh Janati、Majid M. Heravi、Ahmad Mir Shokraie

  DOI：10.1080/15533174.2012.762381

  日期：2015.1.2

  A series of 1-(alpha-aminoalkyl) naphthols were synthesized expeditiously in good yields and selectivity from 2-naphthol, alkylamines and aldehydes in the presence of nanoparticle Fe3O4 at room temperature in solvent-free conditions.