1,2,3,5-Tetrahydrobenzothiazepin-4-oxid | 1668-77-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1,2,3,5-Tetrahydrobenzothiazepin-4-oxid
• 英文别名: 1,2,3,5-tetrahydro-benzo[e][1,4]thiazepine 4-oxide；1,2,3,5-Tetrahydro-4lambda4,1-benzothiazepine 4-oxide；1,2,3,5-tetrahydro-4λ4,1-benzothiazepine 4-oxide
• CAS: 1668-77-5
• 化学式: C₉H₁₁NOS
• 分子量: 181.258
• InChiKey: NNRHQSFNJCQFEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  48.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Agent for preventing or treating organ functional disorders and organ dysfunction
  申请人：Sugiyama Yasuo

  公开号：US20080132483A1

  公开（公告）日：2008-06-05

  The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.

  本发明提供了一种用于预防或治疗器官功能障碍的药剂，一种用于预防或治疗器官功能紊乱的药剂，以及一种用于预防或治疗肥胖和其代谢疾病的药剂，每种药剂均包括具有增加泛醌或其盐或前药作用的化合物；以及一种增加泛醌的药剂，包括具有角鲨烷合酶抑制作用或其盐或前药的化合物。
• REMEDY FOR XANTHOMA
  申请人：Shiomi Masashi

  公开号：US20090082333A1

  公开（公告）日：2009-03-26

  A preventive/remedy for xanthoma which contains a compound having an inhibitory effect on squalene synthase, its prodrug or its salt.
• Crp Lowering Agent
  申请人：Imura Yoshimi

  公开号：US20090118255A1

  公开（公告）日：2009-05-07

  The present invention provides a novel drug which is useful as a preventive and/or therapeutic agent for various diseases involved in elevation of CRP level, in particular, inflammatory disease and cancer comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.