2-methoxymethyl-chromen-4-one | 223511-45-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-methoxymethyl-chromen-4-one
• 英文别名: 2-Methoxymethyl-chromen-4-on；2-(Methoxymethyl)chromen-4-one
• CAS: 223511-45-3
• 化学式: C₁₁H₁₀O₃
• 分子量: 190.199
• InChiKey: NHMWEVJVITWWEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxymethyl-chromen-4-one 在 氢碘酸 作用下， 生成 2-(hydroxymethyl)-4H-chromen-4-one
  参考文献：
  名称：

  色酮衍生物：紫外吸收光谱；冠状动脉扩张作用

  摘要：

  1.描述了一些简单的色酮衍生物的制备。

  DOI：

  10.1002/hlca.19510340241
• 作为产物：
  描述：

  2-(tert-butyldimethylsilanyloxy)-benzoyl chloride 在 bis-triphenylphosphine-palladium(II) chloride copper(l) iodide 、 二乙胺 、 三乙胺 作用下， 以 乙醇 为溶剂， 反应 39.0h， 生成 2-methoxymethyl-chromen-4-one
  参考文献：
  名称：

  Novel synthetic routes suitable for constructing benzopyrone combinatorial libraries

  摘要：

  A series of O-(t-butylsilyloxy)benzoyl chlorides generated from the corresponding silyl esters were coupled with a range of terminal alkynes to afford the corresponding alkynyl ketones. The alkynyl ketones were converted to enaminoketones and then cyclized to yield the desired benzopyrone ring system. This synthetic protocol utilizes readily available starting materials, mild and high yielding reactions with good functional group tolerance, and is ideal for developing combinatorial libraries centered around the benzopyrone ring system. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00279-8

文献信息

• CHROMEN-4-ONE DERIVATIVES AS SELF-TANNING SUBSTANCE
  申请人：Carola Christophe

  公开号：US20090220438A1

  公开（公告）日：2009-09-03

  The invention relates to the use of compounds of the formula (I), where R 1 and R 2 may be identical or different and stand for H, OH, OCH 3 , CH 3 , CH 2 OH or CH 2 OCH 3 , R 3 stands for H or straight-chain or branched C 1 - to C 20 -alkyl groups, R 4 stands for H or OR 8 , R 5 and R 6 may be identical or different and are selected from —H, —OH, straight-chain or branched C 1 to C 20 -alkyl groups, straight-chain or branched C 3 - to C 20 -alkenyl groups, straight-chain or branched C 1 - to C 20 -hydroxyalkyl groups, where the hydroxyl group may be bonded to a primary or secondary carbon atom of the chain, and furthermore the allyl chain may also be interrupted by oxygen, and R 8 stands for H or straight-chain or branched C 1 - to C 20 -alkyl groups, with the proviso that R 2 does not denote H if R 1 denotes CH 3 , as self-tanning agents, and to compounds and the preparation thereof.

  该发明涉及使用式(I)的化合物，其中R1和R2可能相同也可能不同，代表H、OH、OCH3、CH3、CH2OH或CH2OCH3，R3代表H或直链或支链的C1到C20烷基基团，R4代表H或OR8，R5和R6可能相同也可能不同，选自-H、-OH、直链或支链的C1到C20烷基基团、直链或支链的C3到C20烯基基团、直链或支链的C1到C20羟基烷基基团，其中羟基可能连接到链的一级或二级碳原子上，此外，烯丙基链也可能被氧断裂，R8代表H或直链或支链的C1到C20烷基基团，但要求如果R1代表CH3，则R2不能表示H，作为自日晒剂的化合物，以及其制备方法。
• Chromon-Derivate: UV.-Absorptionsspektren; coronardilatatorische Wirkung
  作者：J. Schmutz、H. Lauener、R. Hirt、M. Sanz

  DOI：10.1002/hlca.19510340241

  日期：——

  1. Es wird die Herstellung einiger einfacher Chromon-Derivate beschrieben.

  1.描述了一些简单的色酮衍生物的制备。
• Novel synthetic routes suitable for constructing benzopyrone combinatorial libraries
  作者：Abhijit S. Bhat、Jennifer L. Whetstone、Robert W. Brueggemeier

  DOI：10.1016/s0040-4039(99)00279-8

  日期：1999.3

  A series of O-(t-butylsilyloxy)benzoyl chlorides generated from the corresponding silyl esters were coupled with a range of terminal alkynes to afford the corresponding alkynyl ketones. The alkynyl ketones were converted to enaminoketones and then cyclized to yield the desired benzopyrone ring system. This synthetic protocol utilizes readily available starting materials, mild and high yielding reactions with good functional group tolerance, and is ideal for developing combinatorial libraries centered around the benzopyrone ring system. (C) 1999 Elsevier Science Ltd. All rights reserved.