1,5-diphenethyl-biguanide | 102956-49-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,5-diphenethyl-biguanide
• 英文别名: 1,5-Diphenaethyl-biguanid；2-(2-phenylethyl)-1-[N'-(2-phenylethyl)carbamimidoyl]guanidine
• CAS: 102956-49-0
• 化学式: C₁₈H₂₃N₅
• 分子量: 309.414
• InChiKey: DUEITVKHBUYICE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  88.8
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Biguanide Derivative, A Preparation Method Thereof And A Pharmaceutical Composition Containing The Biguanide Derivative As An Active Ingredient
  申请人：Kim Sung Wuk

  公开号：US20120283299A1

  公开（公告）日：2012-11-08

  A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

  提供一种具有N1-N5取代的biguanide衍生物化合物，其由Formula 1表示，或其药学上可接受的盐，以及制备该化合物的方法，以及含有该化合物作为活性成分的药物组合物。与传统药物相比，这种biguanide衍生物可能在低剂量下对AMPKα的激活和对癌细胞增殖的抑制表现出出色的效果，因此可能有助于治疗糖尿病、肥胖、高脂血症、高胆固醇血症、脂肪肝、冠心病、骨质疏松症、多囊卵巢综合征、代谢综合征、癌症等疾病。
• BIGUANIDE DERIVATIVE, A PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION CONTAINING THE BIGUANIDE DERIVATIVE AS AN ACTIVE INGREDIENT
  申请人：HanAll Biopharma Co., Ltd.

  公开号：EP2522653A2

  公开（公告）日：2012-11-14

  A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

  本发明提供了一种由式 1 表示的具有 N1-N5 取代的双胍衍生物化合物或其药学上可接受的盐、其制备方法以及以其为活性成分的药物组合物。与传统药物相比，该双胍衍生物可在低剂量下表现出良好的激活 AMPKα 和抑制癌细胞增殖的效果，因此可用于治疗糖尿病、肥胖症、高脂血症、高胆固醇血症、脂肪肝、冠心病、骨质疏松症、多囊卵巢综合征、代谢综合征、癌症等。
• Cleaning formulation for removing residues on surfaces
  申请人：Fujifilm Electronic Materials U.S.A., Inc.

  公开号：US10253282B2

  公开（公告）日：2019-04-09

  This disclosure relates to a cleaning composition that contains 1) at least one redox agent; 2) at least one first chelating agent, the first chelating agent being a polyaminopolycarboxylic acid; 3) at least one second chelating agent different from the first chelating agent, the second chelating agent containing at least two nitrogen-containing groups; 4) at least one metal corrosion inhibitor, the metal corrosion inhibitor being a substituted or unsubstituted benzotriazole; 5) at least one organic solvent selected from the group consisting of water soluble alcohols, water soluble ketones, water soluble esters, and water soluble ethers; 6) water; and 7) optionally, at least one pH adjusting agent, the pH adjusting agent being a base free of a metal ion. This disclosure also relates to a method of using the above composition for cleaning a semiconductor substrate.

  本公开涉及一种清洁组合物，其中包含：1）至少一种氧化还原剂；2）至少一种第一螯合剂，第一螯合剂为聚氨基多羧酸；3）至少一种不同于第一螯合剂的第二螯合剂，第二螯合剂含有至少两个含氮基团；4) 至少一种金属缓蚀剂，该金属缓蚀剂为取代或未取代的苯并三唑； 5) 至少一种有机溶剂，该有机溶剂选自由水溶性醇、水溶性酮、水溶性酯和水溶性醚组成的组； 6) 水；以及 7) 可选地，至少一种 pH 值调节剂，该 pH 值调节剂为不含金属离子的碱。本公开还涉及一种使用上述组合物清洗半导体基底的方法。
• Biguanide derivative, a preparation method thereof, and a pharmaceutical composition containing the biguanide derivative as an active ingredient
  申请人：Immunomet Therapeutics Inc.

  公开号：US10376480B2

  公开（公告）日：2019-08-13

  A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

  本发明提供了一种由式 1 表示的具有 N1-N5 取代的双胍衍生物化合物或其药学上可接受的盐、其制备方法以及以其为活性成分的药物组合物。与传统药物相比，该双胍衍生物可在低剂量下表现出良好的激活 AMPKα 和抑制癌细胞增殖的效果，因此可用于治疗糖尿病、肥胖症、高脂血症、高胆固醇血症、脂肪肝、冠心病、骨质疏松症、多囊卵巢综合征、代谢综合征、癌症等。
• CLEANING FORMULATION FOR REMOVING RESIDUES ON SURFACES
  申请人：FujiFilm Electronic Materials USA, Inc.

  公开号：EP3077129B1

  公开（公告）日：2020-11-11