5-Methyl-3-(1-methylethyl)benzo[b]thiophene | 858819-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 5-Methyl-3-(1-methylethyl)benzo[b]thiophene
• 英文别名: 5-methyl-3-propan-2-yl-1-benzothiophene
• CAS: 858819-97-3
• 化学式: C₁₂H₁₄S
• 分子量: 190.31
• InChiKey: RLZAEAIGLQXKJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS
  申请人：Gilead Sciences, Inc.

  公开号：US20150166546A1

  公开（公告）日：2015-06-18

  The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

  本发明提供了用于治疗病毒感染的化合物及其药学上可接受的盐和酯以及其组合物。这些化合物和组合物对于治疗包括人类呼吸道合胞病毒感染在内的Pneumovirinae病毒感染是有用的。
• US9278975B2
  申请人：——

  公开号：US9278975B2

  公开（公告）日：2016-03-08
• [EN] METHODS FOR TREATING CANCER<br/>[FR] MÉTHODES DE TRAITEMENT DU CANCER
  申请人：[en]SCORPION THERAPEUTICS, INC.

  公开号：WO2022076831A2

  公开（公告）日：2022-04-14

  This disclosure provides chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit epidermal growth factor receptor (EGFR, ERBB1) and/or Human epidermal growth factor receptor 2 (HER2, ERBB2). These chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) EGFR and/or HER2 activation contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also provides compositions containing the same as well as methods of using and making the same.