tert-butyl 1-(2-((1-(5-bromopyridin-2-yl)pyrrolidin-3-yl)(methyl)amino)ethyl)cyclohexanecarboxylate | 1224172-70-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tert-butyl 1-(2-((1-(5-bromopyridin-2-yl)pyrrolidin-3-yl)(methyl)amino)ethyl)cyclohexanecarboxylate
• 英文别名: Tert-butyl 1-[2-[[1-(5-bromopyridin-2-yl)pyrrolidin-3-yl]-methylamino]ethyl]cyclohexane-1-carboxylate
• CAS: 1224172-70-6
• 化学式: C₂₃H₃₆BrN₃O₂
• 分子量: 466.462
• InChiKey: YJKCOWDZNDLPHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  45.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
  申请人：Devasthale Pratik

  公开号：US20110195934A1

  公开（公告）日：2011-08-11

  The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable faints thereof according to wherein all of the variables are defined herein.

  本申请提供了化合物，包括所有立体异构体、溶剂化物、前药和药学上可接受的盐，其中所有变量在此定义。
• US8415386B2
  申请人：——

  公开号：US8415386B2

  公开（公告）日：2013-04-09
• [EN] AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR-1 DE L'HORMONE DE MÉLANO-CONCENTRATION D'AZOLOPYRROLONE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010047956A1

  公开（公告）日：2010-04-29

  The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula (I) including all pharmaceutically acceptable salts and stereoisomers thereof: wherein A is a monocyclic aryl or monocyclic heteroaryl; W is a direct bond, -0-, or -N(R6)-, provided that if W is a direct bond, D must be a cyclic amine that is attached to A via the nitrogen atom of said cyclic amine; D is a direct bond, substituted or unsubstituted C1 to C4 alkyl, substituted or unsubstituted C3 to C7 cycloalkyl, cycloalkylalkyl, or a 4 to 6 membered cyclic amine; B and E are independently N or CH provided that both are not CH;