1-methylisoselenochromene | 220799-36-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 1-methylisoselenochromene
• 英文别名: 1-methyl-1H-isoselenochromene
• CAS: 220799-36-0
• 化学式: C₁₀H₁₀Se
• 分子量: 209.149
• InChiKey: MVPRHVWJWOPICI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-methylisoselenochromene 在 trityl tetrafluoroborate 作用下， 以 硝基甲烷 为溶剂， 反应 2.0h， 以92%的产率得到1-methyl-2-benzoselenopyrylium trtrafluoroborate
  参考文献：
  名称：

  Reactions of 2-Benzoselenopyrylium Salts with Hydrazine: A New Easy Access to 5H-2,3-Benzodiazepines

  摘要：

  While the solvent-free reactions of the 2-benzoselenopyrylium salts (9) with methyl- or phenylhydrazine afforded the 1-hydrazino-1H-isoselenochromenes (11, 12), the treatment of the salts (9) with anhydrous hydrazine in dry acetonitrile resulted in a ring transformation to give the 5H-2,3-benzodiazepines (13) in one-pot under mild conditions in moderate yields.

  DOI：

  10.1248/cpb.53.60
• 作为产物：
  描述：

  甲基碘化镁 、 2-benzoselenopyrylium tetrafluoroborate 以 乙醚 为溶剂， 反应 0.5h， 以24%的产率得到1-methylisoselenochromene
  参考文献：
  名称：

  Reactions of 2-Benzoselenopyrylium Salts with Hydrazine: A New Easy Access to 5H-2,3-Benzodiazepines

  摘要：

  While the solvent-free reactions of the 2-benzoselenopyrylium salts (9) with methyl- or phenylhydrazine afforded the 1-hydrazino-1H-isoselenochromenes (11, 12), the treatment of the salts (9) with anhydrous hydrazine in dry acetonitrile resulted in a ring transformation to give the 5H-2,3-benzodiazepines (13) in one-pot under mild conditions in moderate yields.

  DOI：

  10.1248/cpb.53.60

文献信息

• Reaction of 2-Benzoselenopyrylium Salts with Nucleophiles: Formation of 1-Functionalized Isoselenochromenes
  作者：Haruki Sashida、Kazuo Ohyanagi

  DOI：10.3987/com-98-8384

  日期：——

  1-Unsubstituted isoselenochromenes (3) were converted into the 2-benzoselenopyrylium salts (4) by treatment with Ph3C+BF4- and the reaction of the salts (4) with several nucleophilic reagents (alcohol, amine, cyanide, acetone, and Grignard reagents) afforded the corresponding 1-functionalized isoselenochromenes (5-9) in high yields, respectively. 1-Alkyl- and 1-phenyl-2-benzoselenopyrylium salts (10) were also obtained from 9.