2-anilino-7-(3,4-dihydro-1H-isoquinolin-2-yl)-1-phenyl-5-(trifluoromethyl)-1,8-naphthyridin-4-one | 503435-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-anilino-7-(3,4-dihydro-1H-isoquinolin-2-yl)-1-phenyl-5-(trifluoromethyl)-1,8-naphthyridin-4-one
• CAS: 503435-51-6
• 化学式: C₃₀H₂₃F₃N₄O
• 分子量: 512.534
• InChiKey: RQYZNMXXQYXUEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS<br/>[FR] DERIVES DE 1,6-NAPHTYRIDINE ET 1,8-NAPHTYRIDINE ET LEUR UTILISATION POUR LE TRAITEMENT DU DIABETE ET DE TROUBLES ASSOCIES
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2005091857A2

  公开（公告）日：2005-10-06

  The invention relates generally to naphthyridine derivatives of the formula (A) wherein one of U, X, Y and Z is nitrogen and the others are C-R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine and 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.