5-Isopropyl-benzothiophen | 17514-98-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 5-Isopropyl-benzothiophen
• 英文别名: 5-isopropyl-benzo[b]thiophene；5-Propan-2-yl-1-benzothiophene
• CAS: 17514-98-6
• 化学式: C₁₁H₁₂S
• 分子量: 176.282
• InChiKey: CTRVZAPEPIMXKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I" PATHWAY AND METHODS OF USE THEREOF
  申请人：Kineta Immuno-Oncology LLC

  公开号：US20200055871A1

  公开（公告）日：2020-02-20

  The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

  本发明涉及式（I）化合物，该化合物是RIG-I通路的激活剂。
• Pyridine- and Pyrimidinecarboxamides as CXCR2 Modulators
  申请人：Maeda Dean Y.

  公开号：US20100210593A1

  公开（公告）日：2010-08-19

  There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.

  披露了作为药物剂的吡啶和嘧啶羧酰胺化合物，合成过程以及包括吡啶和嘧啶羧酰胺化合物的药物组合物。更具体地，披露了一类CXCR2抑制剂化合物，可用于治疗各种炎症和肿瘤性疾病。
• INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20200069646A1

  公开（公告）日：2020-03-05

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the disclosure.

  披露了调节或抑制吲哚胺2,3-双加氧酶（IDO）酶活性的化合物，包含所述化合物的药物组合物以及使用本披露的化合物治疗增殖性疾病的方法，如癌症、病毒感染和/或炎症性疾病。
• [EN] SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME<br/>[FR] COMPOSÉS SPIROCYCLIQUES ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION DE CEUX-CI
  申请人：ABIDE THERAPEUTICS INC

  公开号：WO2019046318A1

  公开（公告）日：2019-03-07

  Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

  本文提供的化合物和组合物可用作MAGL的调节剂。此外，这些化合物和组合物可用于治疗疼痛。
• [EN] SMALL MOLECULE DEGRADERS OF STAT3<br/>[FR] AGENTS DE DÉGRADATION, À PETITES MOLÉCULES, DE STAT3
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2020198435A1

  公开（公告）日：2020-10-01

  The present disclosure provides compounds represented by Formula I or Formula VIII: wherein R1a, R1b, M, A, E, QA, and QB are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are degraders of STAT3 or dedraders of STAT3 and STAT1. Compounds of Formula VIII are inhibitors of STAT3. STAT3 degraders and inhibitors are useful for the treatment of cancer and other diseases.

  本公开提供由公式I或公式VIII表示的化合物：其中R1a、R1b、M、A、E、QA和QB如规范中定义，并其盐和溶剂合物。公式I的化合物是STAT3的降解物或STAT3和STAT1的去除物。公式VIII的化合物是STAT3的抑制剂。STAT3的降解物和抑制剂对于癌症和其他疾病的治疗是有用的。