(2S)-1-((2S)-2-(4-fluoro-2-methoxyphenyl)-2-hydroxyethyl)-2-methyl-7-morpholin-4-yl-2-trifluoromethyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one | 1260983-70-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2S)-1-((2S)-2-(4-fluoro-2-methoxyphenyl)-2-hydroxyethyl)-2-methyl-7-morpholin-4-yl-2-trifluoromethyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one
• 英文别名: (2S)-1-[(2S)-2-(4-fluoro-2-methoxyphenyl)-2-hydroxyethyl]-2-methyl-7-morpholin-4-yl-2-(trifluoromethyl)-3H-imidazo[1,2-a]pyrimidin-5-one
• CAS: 1260983-70-7
• 化学式: C₂₁H₂₄F₄N₄O₄
• 分子量: 472.44
• InChiKey: QGMDTGARIGJNPL-QRWLVFNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  77.8
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• NOVEL 2,3-DIHYDRO-1H-IMIDAZO(1,2-A)PYRIMIDIN-5-ONE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF
  申请人：Brolio Maurice

  公开号：US20120142679A1

  公开（公告）日：2012-06-07

  The invention relates to the novel materials of formula (I), where R 1 is an optionally substituted L-aryl or -heteroaryl, such that L is: an alkyl or CO, or L X, with L being an alkyl and X being O or S; R 2 is H or an alkyl; R 3 is an alkyl optionally substituted by Hal; and R 4 is Hou Hal, wherein said materials are in any isomeric form and the salts thereof, to be used as drugs.

  本发明涉及式（I）的新材料，其中R1是可选取的取代L-芳基或杂芳基，其中L是：烷基或CO，或LX，其中L是烷基，X是O或S；R2是氢或烷基；R3是可选取的Hal取代的烷基；R4是H或Hal，其中所述材料以任何异构体形式及其盐的形式用作药物。
• DERIVES DE 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：SANOFI

  公开号：EP2448939B1

  公开（公告）日：2017-03-01
• ADHESIVES AND SEALANTS CONTAINING CYCLOHEXANE POLYCARBOXYLIC ACID DERIVATIVES
  申请人：Wagner Jochen

  公开号：US20120138206A1

  公开（公告）日：2012-06-07

  The invention relates to an adhesive or sealant comprising at least (A) 10% to 90% by weight of a compound selected from the group consisting of polyurethanes, polyureas, polyacrylates and polysulphides and at least (B) 1% to 50% by weight of a cyclohexanepolycarboxylic acid derivative, the adhesive or sealant containing no C 4 to C 8 alkyl terephthalate. The composition features a low glass transition temperature and also a low dirt pick-up tendency, without detriment to the further performance properties. An additional advantage of the proposed adhesives and sealants lies in their well-balanced mechanical properties. A process for preparing them, and their use for material bonds between parts to be joined, are disclosed.
• US8828997B2
  申请人：——

  公开号：US8828997B2

  公开（公告）日：2014-09-09