bis(2-propyl-pentanoate)(1,10-phenanthroline)copper (II) | 199331-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: bis(2-propyl-pentanoate)(1,10-phenanthroline)copper (II)
• 英文别名: [Cu(Valp)₂Phen]；[Cu(2-propyl-pentanoate)₂(1,10-phenanthroline)]；bis-(2-propylpentanoato)(1,10-phenanthroline)copper(II)；Copper;1,10-phenanthroline;2-propylpentanoate
• CAS: 199331-09-4
• 化学式: C₂₈H₃₈CuN₂O₄
• 分子量: 530.167
• InChiKey: JAERJFWIQCNFRN-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  4.69
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 Cu₂(Valp)₄ 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以45%的产率得到bis(2-propyl-pentanoate)(1,10-phenanthroline)copper (II)
  参考文献：
  名称：

  THERAPEUTICAL USE OF TERNARY COMPLEXES OF VALPROIC ACID

  摘要：

  一种治疗对戊二酸疗法有反应的人体患者的方法，包括向患者施用有效剂量的基于金属的戊二酸三元配合物，其中与二亚胺或二胺特别配合的氮供体配体。

  公开号：

  US20120142658A1

文献信息

• THERAPEUTICAL USE OF TERNARY COMPLEXES OF VALPROIC ACID
  申请人：Sylla-Iy Arreta Veitia Maite

  公开号：US20120142658A1

  公开（公告）日：2012-06-07

  A method of treating a human subject having a condition responsive to valproic acid therapy, includes administering to the subject an effective amount of a metal-based ternary complex of valproic acid with nitrogen donor ligands, in particular with diimines or diamines.

  一种治疗对戊二酸疗法有反应的人体患者的方法，包括向患者施用有效剂量的基于金属的戊二酸三元配合物，其中与二亚胺或二胺特别配合的氮供体配体。
• Mixed Ternary Mononuclear Copper(II) Complexes Based on Valproic Acid with 1,10-Phenanthroline and 2,2’-Bipyridine Ligands: DNA Interaction and Cytotoxicity in V79 Cells
  作者：Claus Pich、Paulo dos Santos、Tatiana Fortunato、Marilda Chiarello、Iuri de Oliveira、Bárbara Soares、Nour Ghermani、Miriana Machado、Mariana Roesch-Ely、Françoise Dumas、Hernan Terenzi、João Henriques、Sidnei Moura

  DOI：10.21577/0103-5053.20180229

  日期：——

  This paper reports the DNA interaction and cytotoxicity of binary and ternary copper(II) complexes of valproic acid with phenanthroline or bipyridine and the complementary characterization of Cu(Valp)(2) Bipy by crystallography. Circular dichroism, plasmid and oligonucleotide assays have shown that the complexes interact with DNA in different manners and are able to cleave plasmid DNA and oligonucleotides at concentrations from 10 to 1000 mol L-1. The plasmid DNA cleavage is enhanced 650, 375 and 285 times by photo activation with UVB light for the complexes Cu(Valp)(2)Phen, Cu(Valp)(2)Bipy and Cu-2(Valp)(4), respectively. Cytotoxicity assays demonstrated that V79 cells were more sensitive to Cu-II derivatives than sodium valproate as evaluated by 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide (MTT) and clonogenic assays, where the cytotoxic profile of the compounds was: Cu(Valp)(2)Phen higher than Cu(Valp)(2)Bipy, higher than Cu-2(Valp)(4). Therefore, we report two copper complexes, which interact with DNA and promote its cleavage, leading to an enhanced cytotoxicity when compared to valproic acid.