(2R,3R)-2-bromo-3-hydroxy-3-phenylpropanoic acid | 130853-41-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (2R,3R)-2-bromo-3-hydroxy-3-phenylpropanoic acid
• CAS: 130853-41-7
• 化学式: C₉H₉BrO₃
• 分子量: 245.073
• InChiKey: PNZTVDQYHQRHKB-HTQZYQBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Stereoselective chemoenzymatic process for the preparation of optically enriched phenylglycidates as precursors of taxol side chain
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL

  公开号：US20040259943A1

  公开（公告）日：2004-12-23

  The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two enantiomers of trans alkyl phenylglycidate i.e. alkyl(2S,3R)-phenylglycidate and alkyl(2R,3S)-phenylglycidate of formulae 7 and 8 respectively. 1

  本发明涉及一种新颖有效的化学酶法制备光学活性反式烷基苯基乙二酸酯的方法。该发明特别揭示了一种新的化学酶法合成反式烷基苯基乙二酸酯的两个对映异构体，即式7和式8的烷基(2S,3R)-苯基乙二酸酯和烷基(2R,3S)-苯基乙二酸酯。
• STEREOSELECTIVE CHEMOENZYMATIC PROCESS FOR PREPARING OPTICALLY ENRICHED PHENYLGLYCIDATES
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：EP1601778A1

  公开（公告）日：2005-12-07
• [EN] STEREOSELECTIVE CHEMOENZYMATIC PROCESS FOR PREPARING OPTICALLY ENRICHED PHENYLGLYCIDATES<br/>[FR] PROCEDE CHIMIOENZYMATIQUE STEREOSELECTIF POUR LA PREPARATION DE PHENYLGLYCIDATES OPTIQUEMENT ENRICHIS
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2004081219A1

  公开（公告）日：2004-09-23

  The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two enantiomers of trans alkyl phenylglycidate i.e. alkyl(2S,3R)-phenylglycidate and alkyl(2R,3S)-phenylglycidate of formulae 7 and 8 respectively.