tetra-N-propyl-butanediyldiamine | 78987-84-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tetra-N-propyl-butanediyldiamine
• 英文别名: Tetra-N-propyl-butandiyldiamin；N,N,N',N'-tetrapropyl-1,4-butanediamine；N,N,N',N'-tetrapropylbutane-1,4-diamine
• CAS: 78987-84-5
• 化学式: C₁₆H₃₆N₂
• 分子量: 256.475
• InChiKey: VEFSEKIJPJNXBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 镍 作用下， 生成 tetra-N-propyl-butanediyldiamine
  参考文献：
  名称：

  The Action of Ammonia and Amines on 1,4-Dichloro-2-butene¹

  摘要：

  DOI：

  10.1021/ja01149a061

文献信息

• [EN] SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF<br/>[FR] SOLVANTS COMMUTABLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV KINGSTON

  公开号：WO2011050469A1

  公开（公告）日：2011-05-05

  A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO2, is described. The hydrophilic liquid form is readily converted back to the hydrophobic liquid form and water. The hydrophobic liquid is an amidine or amine. The hydrophilic liquid form comprises an amidinium salt or an ammonium salt.

  描述了一种溶剂，当与水和选择的触发器（例如与CO2接触）接触时，可从疏水液态形式可逆地转变为亲水液态形式。亲水液态形式很容易转变回疏水液态形式和水。疏水液态是一种酰胺或胺。亲水液态形式包括酰胺盐或铵盐。
• Novel benzothiazepine and bensothiepine compounds
  申请人：Sasahara Takehiko

  公开号：US20070190041A1

  公开（公告）日：2007-08-16

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substitutent:

  提供了一种药物，可用作治疗和预防高脂血症的治疗剂和预防剂，以及一种药物，可用作治疗和预防与胆汁淤积有关的肝脏疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的治疗剂和预防剂，以及一种药物，可用作治疗和预防肥胖症、脂肪肝和脂肪性肝炎的治疗剂和预防剂。化合物的苯并噻吩或苯并噻环代表如下式（1A），具有硫酰胺键和季铵取代基：
• Novel quaternary ammonium compounds
  申请人：Sasahara Takehiko

  公开号：US20070203115A1

  公开（公告）日：2007-08-30

  A method for inhibiting ileal bile acid transporter activity in a subject, comprising administering to said subject an effective amount of a compound represented by formula (1):

  一种抑制回肠胆汁酸转运蛋白活性的方法，包括向该受试者施用一种由式（1）所代表的化合物的有效量：
• NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS
  申请人：SASAHARA Takehiko

  公开号：US20120015925A1

  公开（公告）日：2012-01-19

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substituent:

  提供了一种作为治疗剂和预防剂用于高脂血症的药物，以及一种作为治疗剂和预防剂用于与胆汁淤积相关的肝疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的药物，以及一种作为治疗剂和预防剂用于肥胖症、脂肪肝和脂肪性肝炎的药物。该药物是一种具有硫酰胺键和季铵基取代基的苯并噻吩或苯并噻吩化合物，其化学式为（1A）。
• Switchable Hydrophilicity Solvents and Methods of Use Thereof
  申请人：Jessop Philip G.

  公开号：US20110257334A1

  公开（公告）日：2011-10-20

  A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO 2 , is described. The hydrophilic liquid form is readily converted back to the hydrophobic liquid form and water. The hydrophobic liquid is an amidine or amine. The hydrophilic liquid form comprises an amidinium salt or an ammonium salt.

  描述了一种溶剂，当与水和选择的触发器（例如，与CO2接触）接触时，可从疏水液态形式可逆地转换为亲水液态形式。亲水液态形式很容易转换回疏水液态形式和水。疏水液体是一种酰胺或胺。亲水液态形式包括酰胺盐或铵盐。