Tri-(2-phenyl-2-hydroxyaethyl)-amin | 110057-85-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Tri-(2-phenyl-2-hydroxyaethyl)-amin
• 英文别名: Tris-<2-phenyl-2-hydroxy-aethyl>-amin；tris-(β-hydroxy-phenethyl)-amine；Tris-(β-hydroxy-phenaethyl)-amin；α,α',α"-[Nitrilotris(methylene)]trisbenzenemethanol；alpha,alpha',alpha"-[Nitrilotris(methylene)]trisbenzenemethanol；2-[bis(2-hydroxy-2-phenylethyl)amino]-1-phenylethanol
• CAS: 110057-85-7
• 化学式: C₂₄H₂₇NO₃
• 分子量: 377.483
• InChiKey: LLIFRAVJIJSSCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  titanium(IV) isopropylate 、 Tri-(2-phenyl-2-hydroxyaethyl)-amin 以 乙醚 、 甲苯 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  A New Class of Mono- and Tetra-nuclear Titanatranes:  Synthesis, Structure, and Ethylene Polymerization Studies. Role of Single-Sited Active Species?

  摘要：

  Mono- and tetranuclear titanatranes bearing the C-3-symmetric aminotriol ligand N(CH2CHPhOH)(3) were synthesized. The structure of the tetratitanium compound was determined by single-crystal X-ray crystallography. The new titanatrane derivative included four aminotriols ligated to four titanium atoms, forming a tetranuclear unit with mu(2)-O and mu(3)-O bridges. The mono- and tetranuclear titanatranes were capable of polymerizing ethylene with a turnover frequency of up to 375 kg of PE/((mol of catalyst) h bar). The polymers obtained had T-m approximate to 133 degreesC, indicative of linear polyethylene, and were further characterized by NMR. The ethylene polymerization activities of mono- and tetranuclear titanium catalysts were related by a factor of 4, indicating possibly the formation of a common single-site active species.

  DOI：

  10.1021/om034408r
• 作为产物：
  描述：

  1-(2-羟基-2-苯基乙基)吡咯烷-2,5-二酮 在 盐酸 作用下， 生成 Tri-(2-phenyl-2-hydroxyaethyl)-amin
  参考文献：
  名称：

  [关于苯乙烯的氨解，制备苯基氨基乙醇。第四部分 环氧化物的氨解]。

  摘要：

  DOI：

  10.1002/ardp.19592921212
• 作为试剂：
  描述：

  四氢吡咯 在 四氢化物钛 、 Tri-(2-phenyl-2-hydroxyaethyl)-amin molecular sieve 、 过氧化氢异丙苯 作用下， 以 氯仿 为溶剂， 反应 2.5h， 以45%的产率得到1-pyrroline N-oxide
  参考文献：
  名称：

  一种“防水”催化剂，用于通过烷基氢过氧化物将仲胺氧化为硝酮

  摘要：

  首次证明了使用烷基氢过氧化物作为伯氧化剂将仲胺催化氧化为硝酮。通过紧密结合的三烷醇胺配体和分子筛的结合使用，可保护烷氧基钛催化剂免受副产物水的影响。在均质，无水条件下，甚至在没有溶剂的情况下，也可以高产率（高达98％）获得亚硝基。反应速度快（2–7小时），使用低至1％的催化剂即可实现良好的选择性。

  DOI：

  10.1016/s0040-4039(02)02490-5

文献信息

• Derivatives of 2-amino-1-phenylethanol having antiulcer activity
  申请人：A. H. Robins Company, Incorporated

  公开号：US05171753A1

  公开（公告）日：1992-12-15

  Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted phenyl and C is a linking group or terminal group. The compounds of this invention can inhibit ulceration in in-vivo studies in rats.

  2-氨基-1-苯基乙醇的衍生物通过取代胺和苯偶姻、芪氧化物或苯乙烯氧化物制备，得到如下通式的化合物：##STR1## 其中R为H或(未)取代的苯基，C为连接基团或端基团。本发明的这些化合物能够在体内研究中抑制大鼠的溃疡形成。
• Compositions of oxygenated amines and quinone methides as antifoulants for vinylic monomers
  申请人：Ecolab USA Inc.

  公开号：US10869444B2

  公开（公告）日：2020-12-22

  Described are compositions and methods for inhibiting polymerization of a monomer (e.g., styrene) composition a quinone methide polymerization retarder and an oxygen-containing amine compound that is a tertiary amine or hydroxylamine. In a mixture, the oxygen-containing amine compound improves the efficacy of the quinone methide polymerization retarder and provides greater antipolymerant activity. In turn, the mixture reduces or prevents apparatus fouling and improves the purity of monomer streams.

  本发明描述了抑制单体（如苯乙烯）聚合的组合物和方法，组合物包括甲脒醌聚合延缓剂和含氧胺化合物（叔胺或羟胺）。在混合物中，含氧胺化合物可提高甲脒醌类聚合延缓剂的功效，并提供更强的抗聚合活性。反过来，混合物还能减少或防止装置堵塞，提高单体流的纯度。
• Early Transition Metal Alkoxide Complexes Bearing Homochiral Trialkanolamine Ligands
  作者：William A. Nugent、Richard L. Harlow

  DOI：10.1021/ja00093a011

  日期：1994.7

  Enantiomerically pure trialkanolamines of the formula N(CH(2)CHROH)(3), where R = methyl (3a), cyclohexyl (3b), tert-butyl (3c), or phenyl (3d), are readily synthesized by the reaction of ammonia with 3 equiv of an enantiopure epoxide. Trialkanolamines 3a-d replace n-propanol in tri-n-propyl vanadate to afford corresponding complexes 4a-d of the formula LV=O, where L is the deprotonated trialkanolamine. Similarly, (S,S,S)-triisopropanolamine 3a reacts with Ti((OPr)-Pr-i)(4) to produce monomeric LTi((OPr)-Pr-i), 7a, which upon treatment with acetyl chloride gives the chloro complex LTiCl, 7b. The later group 5 ethoxides react with 3a to produce LM(OEt)(2) (M = Nb, Ta). Partial hydrolysis of the Nb and Ta derivatives produces tetrameric mu-oxo-bridged structures which retain the trialkanolamine ligands. In all complexes the transition metal resides in a highly asymmetric environment, suggesting that this class of complexes may find use in the field of asymmetric catalysis. The X-ray crystal structures of complexes 4c and 7b are reported.
• US5171753A
  申请人：——

  公开号：US5171753A

  公开（公告）日：1992-12-15