2-hydrazino-3-phenylquinazoline-4(3H)-hydrazone | 10262-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-hydrazino-3-phenylquinazoline-4(3H)-hydrazone
• 英文别名: 2-hydrazinyl-4-hydrazono-3-phenyl-3,4-dihydroquinazoline；2-Hydrazino-3-phenylchinazolo-4-hydrazon
• CAS: 10262-23-4
• 化学式: C₁₄H₁₄N₆
• 分子量: 266.305
• InChiKey: GOHKUEOGURDPFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.09
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.25
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  3-苯基-2-硫代-2,3-二氢-4(1H)-喹唑啉酮 在 hydrazine hydrate 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 以55%的产率得到2-hydrazino-3-phenylquinazoline-4(3H)-hydrazone
  参考文献：
  名称：

  Spectral Characterization of Novel 3-Phenyl-2-Substituted Quinazoline and Fused Quinazoline Derivatives

  摘要：

  3-phenyl-2-thioxo-quinazolin-4(3H)one 1 was utilized for the construction of some novel 2-substituted quinazolin-4(3H)one derivatives through the formation of 2-hydrazinyl quinazolinone, which was used as the key starting material for the synthesis of 2-heteryl quinazolines via the reaction with one carbon donors, -diketones and -ketoester. Infrared, H-1 NMR, and mass spectra of the synthesized compounds were discussed. Some of them showed promising anti-inflammatory activity. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2011.642924