5-Ethyl-6-fluoro-2,7-bis(4-fluoroanilino)-1-(4-fluorophenyl)-1,8-naphthyridin-4-one | 503435-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 5-Ethyl-6-fluoro-2,7-bis(4-fluoroanilino)-1-(4-fluorophenyl)-1,8-naphthyridin-4-one
• CAS: 503435-75-4
• 化学式: C₂₈H₂₀F₄N₄O
• 分子量: 504.487
• InChiKey: VGPGKNHPKQHGJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.3
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS<br/>[FR] DERIVES 1, 8-NAPHTYRIDINE UTILISES COMME ANTIDIABETIQUES
  申请人：BAYER AG

  公开号：WO2003027112A1

  公开（公告）日：2003-04-03

  The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C-R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.

  本发明涉及公式的萘啶衍生物，其中U、X、Y和Z中的一个是氮，其余为C-R，其中R是氢或取代基。更具体地，本发明涉及1,8-萘啶衍生物和含有这种衍生物的药物组合物。本发明的方法包括给予本发明的萘啶衍生物治疗糖尿病及相关疾病。
• [EN] 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS<br/>[FR] DERIVES DE 1,6-NAPHTYRIDINE ET 1,8-NAPHTYRIDINE ET LEUR UTILISATION POUR LE TRAITEMENT DU DIABETE ET DE TROUBLES ASSOCIES
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2005091857A2

  公开（公告）日：2005-10-06

  The invention relates generally to naphthyridine derivatives of the formula (A) wherein one of U, X, Y and Z is nitrogen and the others are C-R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine and 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.