1-[2-[2-[2-[Bis(2-hydroxydodecyl)amino]ethoxy]ethoxy]ethylamino]dodecan-2-ol | 1220890-35-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[2-[2-[2-[Bis(2-hydroxydodecyl)amino]ethoxy]ethoxy]ethylamino]dodecan-2-ol
• CAS: 1220890-35-6
• 化学式: C₄₂H₈₈N₂O₅
• 分子量: 701.171
• InChiKey: BPHYECVYVJHZPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.8
• 重原子数：
  49
• 可旋转键数：
  42
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  94.4
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• DELIVERY OF COATED HYDROPHOBIC ACTIVE AGENT PARTICLES
  申请人：SURMODICS, INC.

  公开号：US20130190689A1

  公开（公告）日：2013-07-25

  Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.
• COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS
  申请人：SurModics, Inc.

  公开号：US20140142166A1

  公开（公告）日：2014-05-22

  Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.
• DELIVERY OF HYDROPHOBIC ACTIVE AGENT PARTICLES
  申请人：SurModics, Inc.

  公开号：US20150140107A1

  公开（公告）日：2015-05-21

  Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
• DRUG-CONTAINING PARTICULATE COMPOSITION WITH CATIONIC AGENT, ASSOCIATED MEDICAL DEVICES, AND METHODS FOR TREATMENT
  申请人：Surmodics, Inc.

  公开号：US20170281557A1

  公开（公告）日：2017-10-05

  The disclosure provides bioactive agent-containing particulates that include bioactive agent, biocompatible polymer, negatively charged groups, and a cationic agent. The particulates can be associated with a medical device, such as a balloon catheter, which can be used to move the particulates to a treatment site. Transfer of the particulates from the device to tissue is facilitated by the arrangement of the cationic and bioactive agent-containing particulates.
• LOCALIZED TREATMENT OF TISSUES THROUGH TRANSCATHETER DELIVERY OF ACTIVE AGENTS
  申请人：Surmodics, Inc.

  公开号：US20170281914A1

  公开（公告）日：2017-10-05

  Embodiments herein include catheters and methods for the localized treatment of tissues through transcatheter delivery of active agents. In an embodiment, a method herein can include inserting a catheter into the lumen of a blood vessel. The catheter can include an inflatable balloon, a first lumen within the shaft for delivering a fluid to inflate the balloon, an active agent delivery port, and a second lumen disposed within the shaft for delivering the active agent composition through the shaft to the active agent delivery port. The method can include inflating the balloon to at least partially occlude the flow of blood through the blood vessel. The method can include ejecting the active agent composition from the active agent delivery port into the blood vessel. In an embodiment, a catheter for treating a localized region of the body with an active agent composition is included. Other embodiments are also included herein.