2-phenyl-5-piperidinothiophene | 87061-59-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-phenyl-5-piperidinothiophene
• 英文别名: 1-(5-Phenyl-2-thienyl)piperidine；1-(5-phenylthiophen-2-yl)piperidine
• CAS: 87061-59-4
• 化学式: C₁₅H₁₇NS
• 分子量: 243.373
• InChiKey: OMRCVOVIYQTERQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-phenyl-4-(piperidin-1-yl)butane-1,4-dione 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 0.17h， 以82%的产率得到2-phenyl-5-piperidinothiophene
  参考文献：
  名称：

  从双功能底物制备取代的噻吩、噻唑和 1,3,4-噻二唑-2(3H)-噻吩的新方法和简便方法

  摘要：

  LR（Lawesson 试剂）与 4-氧代羧酸衍生物 I、N-酰基氨基酸衍生物 III 和 N-酰基-N'-乙氧基羰基肼 V 的反应顺利产生取代的噻吩 II、噻唑 IV 和 1,3,4-噻二唑-2(3H)-硫酮 VI.

  DOI：

  10.1246/cl.1983.809

文献信息

• Human androgen receptor DNA-binding domain (DBD) compounds as therapeutics and methods for their use
  申请人：The University of British Columbia

  公开号：US10011573B2

  公开（公告）日：2018-07-03

  A compound having the structure of Formula I, wherein A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and E is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ovarian, endometrial or bladder cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, precocious puberty and age related macular degeneration. The use of the compounds for the manufacture of a medicament for modulating AR activity, a method of treatment using such compounds and a pharmaceutical composition and a commercial package comprising said compounds are also described.

  具有式 I 结构的化合物，其中 A 是取代或未取代的芳基或杂芳基，D 是取代或未取代的 5 或 6 元杂芳基或杂环基，E 是取代或未取代的芳基、杂芳基、环烷基或杂环基。这些化合物可用于治疗雄激素调节适应症，包括癌症（前列腺癌、乳腺癌、卵巢癌、子宫内膜癌或膀胱癌）、脱发、痤疮、多毛症、卵巢囊肿、多囊卵巢病、性早熟和老年性黄斑变性。此外，还描述了这些化合物在制造调节 AR 活性的药物中的用途、使用这些化合物的治疗方法以及包含上述化合物的药物组合物和商业包装。
• “Naked Nickel”-Catalyzed Amination of Heteroaryl Bromides
  作者：Rakan Saeb、Bryan Boulenger、Josep Cornella

  DOI：10.1021/acs.orglett.4c01738

  日期：2024.7.19

  In this Letter, we report that the air-stable “naked nickel” [Ni(4-tBustb)3] is a competent catalyst in thermal C–N bond formation between (hetero)aryl bromides and N-based nucleophiles. The catalytic system is characterized by a “naked nickel” complex and Zn and by the absence of external light sources, photocatalysts, exogenous ligands, and electrical setups. Upon application of this method, various

  在这封信中，我们报道了空气稳定的“裸镍”[Ni( 4- t Bu stb) 3 ] 是（杂）芳基溴化物和N基亲核试剂之间热 C-N 键形成的有效催化剂。该催化系统的特点是“裸镍”络合物和锌，并且没有外部光源、光催化剂、外源配体和电气装置。应用该方法后，可以容纳各种带有路易斯碱性杂原子的杂芳基，并直接用一组伯胺和仲胺胺化。
• THOMSEN, I.;PEDERSEN, U.;RASMUSSEN, P. B.;YDE, B.;ANDERSEN, T. P.;LAWESSO+, CHEM. LETT., 1983, N 6, 809-810
  作者：THOMSEN, I.、PEDERSEN, U.、RASMUSSEN, P. B.、YDE, B.、ANDERSEN, T. P.、LAWESSO+

  DOI：——

  日期：——
• HUMAN ANDROGEN RECEPTOR DNA-BINDING DOMAN (DBD) COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE
  申请人：The University of British Columbia

  公开号：US20170183319A1

  公开（公告）日：2017-06-29

  A compound having the structure of Formula I, wherein A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and E is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ovarian, endometrial or blader cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, precocious puberty and age related macular degeneration. The use of the compounds for the manufacture of a medicament for modulating AR activity, a method of treatment using such compounds and a pharmaceutical composition and a commercial package comprising said compounds arc also described.