(2S)-2,6-diaminohexanoic acid;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid | 68378-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: (2S)-2,6-diaminohexanoic acid;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
• CAS: 68378-41-6
• 化学式: C26H36N10O7
• 分子量: 600.6
• InChiKey: BJJFTSODVHTNCO-NPWGDTHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  43
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  300
• 氢给体数：
  8
• 氢受体数：
  16

文献信息

• Compositions and Methods for Treating Disease Using Salmonella T3SS Effector Protein (SipA)
  申请人：UNIVERSITY OF MASSACHUSETTS

  公开号：US20170035837A1

  公开（公告）日：2017-02-09

  The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising SipA. The invention's compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of P-gp and/or p53. The invention's compositions and methods are useful in reducing cancer symptom and/or cancer multidrug resistance (MDR). The invention provides a method for reducing one or more symptoms of cancer in a mammalian subject in need thereof, comprising administering to said subject a composition comprising purified SipA. In one embodiment, said SipA is operably conjugated to a nanoparticle. In another embodiment, said cancer comprises cancer cells resistant to at least one cytotoxin.

  该发明提供了通过给予含有SipA的组合物来减轻疾病的一个或多个症状的组合物和方法。该发明的组合物和方法在减轻与P-gp和/或p53过表达相关的疾病症状方面特别有优势。该发明的组合物和方法在减轻癌症症状和/或癌症多药耐药性（MDR）方面非常有用。该发明提供了一种用于减轻哺乳动物受试者中的一个或多个癌症症状的方法，包括向所述受试者给予包含纯化SipA的组合物。在一个实施例中，所述SipA与纳米颗粒可操作地结合。在另一个实施例中，所述癌症包括对至少一种细胞毒素具有抗性的癌细胞。
• Compositions and methods for coating medical implants
  申请人：Angiotech Pharmaceuticals, Inc.

  公开号：US20040043052A1

  公开（公告）日：2004-03-04

  Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.

  提供释放蒽环素、氟嘧啶、叶酸拮抗剂、鬼臼毒素、喜树碱、羟基脲和/或铂配合物的医疗植入物，从而抑制或减少与植入物相关的感染的发生率。
• Tissue reactive compounds and compositions and uses thereof
  申请人：Angiotech International AG

  公开号：US20040219214A1

  公开（公告）日：2004-11-04

  A composition comprising a synthetic polymer, optionally in the presence of a drug, where the polymer comprises multiple activated groups. The multiple activated groups are reactive with functionality present on animal tissue, so that upon administration of the polymer to the tissue, the polymer binds to the tissue. Alternatively, the multiple activated groups are reactive with functionality present on a non-living surface, where the polymer binds to this surface to, e.g., increase the lubricity of the surface. When drug is present in the composition, the drug is then delivered to the site of polymer attachment.

  一种组合物包括一种合成聚合物，可选地存在药物，并且该聚合物包括多个活性基团。这些多个活性基团与动物组织上存在的功能性反应，因此在将聚合物注射到组织中时，聚合物与组织结合。或者，这些多个活性基团与非生物表面上存在的功能性反应，聚合物将与该表面结合，例如增加表面的润滑性。当组合物中存在药物时，药物将被传递到聚合物附着的部位。
• Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
  申请人：——

  公开号：US20020055666A1

  公开（公告）日：2002-05-09

  Disclosed herein are therapeutic devices, compositions and methods for treating proliferative diseases. For example, within one aspect of the invention therapeutic devices are provided, comprising a device that locally administers radiation and a cell-cycle inhibitor

  本文公开了治疗增生性疾病的治疗设备、组合物和方法。例如，在发明的一个方面中，提供了治疗设备，包括局部给药放射线和细胞周期抑制剂的设备。
• Compositions and methods for treating diverticular disease
  申请人：Hunter L. William

  公开号：US20050277577A1

  公开（公告）日：2005-12-15

  Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents, and/or anti-infective agents, or compositions containing one or more of these agents are provided for use in methods for treating diverticular disease.

  本文提供治疗结肠憩室病（例如结肠憩室症和结肠憩室炎）的代理人、组合物和植入物。特别地，本文提供诱导纤维化代理人、止血代理人和/或抗感染代理人，或含有这些代理人中的一个或多个的组合物，用于治疗结肠憩室病的方法。