4-溴-2-硝基-1-萘酚 | 905302-18-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-溴-2-硝基-1-萘酚
• 中文别名: 4-溴-2-硝基萘-1-醇
• 英文名称: 4-bromo-2-nitro-[1]naphthol
• 英文别名: 4-Brom-2-nitro-1-hydroxy-naphthalin；4-Brom-2-nitro-[1]naphthol；4-Bromo-2-nitronaphthalen-1-ol
• CAS: 905302-18-3
• 化学式: C₁₀H₆BrNO₃
• 分子量: 268.067
• InChiKey: RYGNNSNXVBBMSK-UHFFFAOYSA-N

物化性质

• 沸点：
  371.5±22.0 °C(Predicted)
• 密度：
  1.787±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2908999090

反应信息

• 作为反应物：
  描述：

  4-溴-2-硝基-1-萘酚 在 盐酸 、 乙醇 、 tin(ll) chloride 作用下， 生成 1-Acetoxy-2-acetamino-4-brom-naphthalin
  参考文献：
  名称：

  Fries; Schimmelschmidt, Justus Liebigs Annalen der Chemie, 1930, vol. 484, p. 245,271

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4-溴-2-硝基萘-1-基)乙酰胺 在 sodium hydroxide 作用下， 生成 4-溴-2-硝基-1-萘酚
  参考文献：
  名称：

  Biedermann; Remmers, Chemische Berichte, 1874, vol. 7, p. 539

  摘要：

  DOI：

文献信息

• p-Toluenesulfonic acid catalyzed regiospecific nitration of phenols with metal nitrates
  作者：V. Anuradha、P.V. Srinivas、P. Aparna、J. Madhusudana Rao

  DOI：10.1016/j.tetlet.2006.05.017

  日期：2006.7

  Highly regiospecific mononitration of phenols and substituted phenols is accomplished employing a metal nitrate and a catalytic amount of p-toluenesulfonic acid in acetone. An exclusive ortho-selectivity was observed with excellent yields. A variety of metal nitrates were used to obtain o-nitrophenols exclusively in good to excellent yields. The use of p-toluenesulfonic acid is key for the selectivity

  使用金属硝酸盐和催化量的对甲苯磺酸在丙酮中，可以实现酚和取代酚的高度区域特异性单硝化。观察到排他的邻位选择性，具有优异的产率。各种金属硝酸盐仅以良好或优异的产率用于获得邻硝基苯酚。对甲苯磺酸的使用是观察到的选择性的关键。
• [EN] NEW BENZIMIDAZOLONE-, BENZOXAZOLONE-, OR BENZOTHIAZOLONE DERIVATIVES AS ION CHANNEL MODULATING AGENTS<br/>[FR] NOUVEAUX DERIVES DE BENZIMIDAZOLONE, DE BENZOXAZOLONE OU DE BENZOTHIAZOLONE AGISSANT COMME AGENTS DE MODULATION DE CANAUX IONIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2000034248A1

  公开（公告）日：2000-06-15

  The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

  本发明涉及离子通道调节剂。更具体地，本发明涉及一类已被证明可用作SKCa、IKCa和BKCa通道调节剂的化学化合物。在进一步的方面，本发明涉及使用这些SK/IK/BK通道调节剂制造药物，以及包含SK/IK/BK通道调节剂的制药组合物。本发明的SK/IK/BK通道调节剂可用于治疗或缓解与SK/IK/BK通道相关的疾病和症状。
• Benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents
  申请人：——

  公开号：US20020055526A1

  公开（公告）日：2002-05-09

  The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SK Ca , IK Ca and BK Ca channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

  本发明涉及离子通道调节剂。更具体地说，本发明涉及一类已被证明对SKCa、IKCa和BKCachannels进行调节有用的化学化合物。在进一步的方面，本发明涉及使用这些SK/IK/BK通道调节剂制造药物，以及包含SK/IK/BK通道调节剂的制药组合物。本发明的SK/IK/BK通道调节剂对于治疗或缓解与SK/IK/BK通道相关的疾病和病症非常有用。
• Ion channel modulating agents comprising novel benzimidazolone derivatives
  申请人：Neurosearch A/S

  公开号：US06624186B2

  公开（公告）日：2003-09-23

  The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

  本发明涉及离子通道调节剂。更具体地，本发明涉及一类已被证明可作为SKCa、IKCa和BKCa通道调节剂的化合物。在进一步的方面，本发明涉及使用这些SK/IK/BK通道调节剂制造药物，以及包括SK/IK/BK通道调节剂的制药组合物。本发明的SK/IK/BK通道调节剂对于治疗或缓解与SK/IK/BK通道相关的疾病和症状是有用的。
• Meldola, Journal of the Chemical Society, 1885, vol. 47, p. 523
  作者：Meldola

  DOI：——

  日期：——