1-Methyl-2-carbamoyl-naphthalin | 91568-91-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Methyl-2-carbamoyl-naphthalin
• 英文别名: 1-Methyl-2-naphthamid；1-methyl-[2]naphthoic acid amide；1-Methyl-[2]naphthoesaeure-amid；1-Methylnaphthalene-2-carboxamide
• CAS: 91568-91-1
• 化学式: C₁₂H₁₁NO
• 分子量: 185.225
• InChiKey: VKODSPVEOQJWTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Methyl-2-carbamoyl-naphthalin 在 氯化亚砜 作用下， 生成 1-甲基萘-2-甲腈
  参考文献：
  名称：

  Further Observations on the Elbs Reaction

  摘要：

  DOI：

  10.1021/jo01067a044
• 作为产物：
  描述：

  1-甲基萘-2-甲腈 在 硫酸 作用下， 生成 1-Methyl-2-carbamoyl-naphthalin
  参考文献：
  名称：

  The Reaction of Cyanogen with Arylmethylmagnesium Halides¹

  摘要：

  DOI：

  10.1021/ja01491a017

文献信息

• [EN] DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1<br/>[FR] UTILISATION DE DIARYLTRIAZOLES COMME INHIBITEURS DE LA 11-BETA-HYDROXYSTEROIDE DESHYDROGENASE-1
  申请人：MERCK & CO INC

  公开号：WO2005097759A1

  公开（公告）日：2005-10-20

  2,5-Diaryl-1,2,4-triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase Type 1 enzyme (11β-HSD-1). The compounds are useful for the treatment of diabetes, hyperglycemia, obesity, insulin resistance, atherosclerosis, dyslipidemia, hyperlipidemia, hypertension, and Metabolic Syndrome. Also disclosed are novel compounds of structural formula II which are inhibitors of 11β-HSD-1.

  2,5-二芳基-1,2,4-三唑衍生物的结构式I是11β-羟基类固醇脱氢酶1型酶（11β-HSD-1）的选择性抑制剂。这些化合物用于治疗糖尿病、高血糖、肥胖、胰岛素抵抗、动脉硬化、血脂异常、高血脂、高血压和代谢综合征。还公开了结构式II的新化合物，它们是11β-HSD-1的抑制剂。
• [EN] NOVEL IMIDAZOLE DERIVATIVES, PRODUCTION METHOD THEREOF AND USE THEREOF<br/>[FR] NOUVEAUX DERIVES IMIDAZOLE, PROCEDE DE PRODUCTION CORRESPONDANT ET UTILISATION DE CES DERIVES
  申请人：TAKEDA CHEMICAL INDUSTRIES LTD

  公开号：WO2002040484A2

  公开（公告）日：2002-05-23

  The present invention provides a compound having a steroid C17,20-lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and a method for efficiently separating an optically active compound of this compound from a mixture of optical isomers thereof, a compound of the formula:wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof, and a method for obtaining an optically active compound by optically resolving a mixture of optical isomers by the use of a resolving agent such as tartranilic acid and the like.

  本发明提供了一种具有类固醇C17,20-裂解酶抑制活性的化合物，用于治疗和预防肿瘤，例如前列腺癌、乳腺癌等，并提供了一种从其光学异构体混合物中高效分离出该化合物的光学活性化合物的方法，该化合物的式为：其中每个符号如规范中所定义，其盐或前药，以及通过使用像酞磺酸等分离剂对光学异构体混合物进行光学分离以获得光学活性化合物的方法。
• Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia
  申请人：JOHN WYETH & BROTHER LIMITED

  公开号：EP0407032A2

  公开（公告）日：1991-01-09

  The invention concerns compounds having formula: or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar¹-A¹-; Ar and Ar¹ are the same or different aryl groups (including heteroaryl) which are optionally substituted, eg by one or more substituents commonly used in pharmaceutical chemistry; A and A¹ are the same or different alkylene groups having one or two carbon atoms linking Ar or Ar¹ to N and optionally substituted by lower alkyl and/or optionally substituted aryl, B is an alkylene group of 3 or 4 carbon atoms, which may be substituted by lower alkyl; D¹ represents halogen, CH₃, CR¹R²NH₂, SO₃H or SO₂NR⁶R⁷ where R¹ and R² are independently hydrogen or lower alkyl and R⁶ and R⁷ are each hydrogen, lower alkyl or aralkyl of 7 to 12 carbon atoms or R⁶ and R⁷ togehter with the nitrogen atom to which they are attached represent a 5 or 6 membered ring, which compounds are useful, for treating depression or cerebral insufficiency or dementias in animals.

  本发明涉及具有以下式子的化合物 或其盐，其中 E 代表氢、低级烷基或基团 Ar¹-A¹-；Ar 和 Ar¹ 是相同或不同的芳基（包括杂芳基），它们被任选取代，例如被药物化学中常用的一个或多个取代基取代；A 和 A¹ 是相同或不同的亚烷基，它们具有一个或两个碳原子，将 Ar 或 Ar¹ 与 N 连接，并任选被低级烷基和/或任选取代的芳基取代，B 是具有 3 或 4 个碳原子的亚烷基，可被低级烷基取代；D¹ 代表卤素、CH₃、CR¹R²NH₂、SO₃H 或 SO₂NR⁶R⁷，其中 R¹ 和 R² 独立地为氢或低级烷基，R⁶ 和 R⁷ 各自为氢、R⁶和 R⁷ 与它们所连接的氮原子一起代表一个 5 或 6 个成员的环，这些化合物可用于治疗动物的抑郁症、脑功能不全或痴呆症。
• NOVEL IMIDAZOLE DERIVATIVES, PRODUCTION METHOD THEREOF AND USE THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1334106A2

  公开（公告）日：2003-08-13
• DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1
  申请人：Merck & Co., Inc.

  公开号：EP1732904A1

  公开（公告）日：2006-12-20