亚丁基二醇丙酸盐 | 90155-19-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 亚丁基二醇丙酸盐
• 中文别名: 克霉唑-氢化可的松
• 英文名称: Canesten HC
• 英文别名: 1-[(2-chlorophenyl)-diphenylmethyl]imidazole;(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 90155-19-4
• 化学式: C43H47ClN2O5
• 分子量: 707.3
• InChiKey: MFXYQIHPQYSOHM-WPUDDCNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.16
• 重原子数：
  51
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：EP1698336A1

  公开（公告）日：2006-09-06

  Pharmaceutical compositions useful for treating dermal diseases caused by fungi and yeasts with inflammation and/or associated with a bacterial infection. Such compositions contain a therapeutically effective amount of Sertaconazole, or a pharmaceutically acceptable salt, solvate, isomer thereof or mixtures thereof; and a therapeutically effective amount of at least one compound selected from the group consisting of Hydrocortisone, a pharmaceutically acceptable ester of Hydrocortisone, an antibacterial agent or mixtures thereof.

  用于治疗真菌和酵母菌引起的皮肤疾病、炎症和/或与细菌感染有关的疾病的药物组合物。此类组合物含有治疗有效量的舍他康唑或其药学上可接受的盐、溶解物、异构体或其混合物；以及治疗有效量的至少一种选自氢可的松、氢可的松药学上可接受的酯、抗菌剂或其混合物的化合物。
• ANTIFUNGAL COMPOSITIONS COMPRISING SERTACONAZOL AND HYDROCORTISONE AND/OR AN ANTIBACTERIAL QUINOLONE COMPOUND
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：EP1858510A1

  公开（公告）日：2007-11-28
• Antifungal Compositions
  申请人：Palacin Celia

  公开号：US20080166398A1

  公开（公告）日：2008-07-10

  Pharmaceutical compositions useful for treating dermal diseases caused by fungi and yeasts with inflammation and/or associated with a bacterial infection. Such compositions contain a therapeutically effective amount of sertaconazole, or a pharmaceutically acceptable salt, solvate, isomer thereof or mixtures thereof; and a therapeutically effective amount of at least one compound selected from the group consisting of hydrocortisone, a pharmaceutically acceptable ester of hydrocortisone, an antibacterial quinolone compound, and mixtures thereof.
• [EN] ANTIFUNGAL COMPOSITIONS COMPRISING SERTACONAZOL AND HYDROCORTISONE AND/OR AN ANTIBACTERIAL QUINOLONE COMPOUND<br/>[FR] COMPOSITIONS ANTIFONGIQUES CONTENANT DE LA SERTACONAZOLE ET DE L'HYDROCORTISONE ET/OU UN COMPOSE DE QUINOLONE ANTIBACTERIEN
  申请人：FERRER INT

  公开号：WO2006092374A1

  公开（公告）日：2006-09-08

  [EN] Pharmaceutical compositions useful for treating dermal diseases caused by fungi and yeasts with inflammation and/or associated with a bacterial infection. Such compositions contain a therapeutically effective amount of sertaconazole, or a pharmaceutically acceptable salt, solvate, isomer thereof or mixtures thereof; and a therapeutically effective amount of at least one compound selected from the group consisting of hydrocortisone, a pharmaceutically acceptable ester of hydrocortisone, an antibacterial quinolone compound, and mixtures thereof.
  [FR] L'invention concerne des compositions pharmaceutiques utiles dans le traitement de maladies dermiques provoquées par des champignons et des levures, présentant une inflammation et/ou associées à une infection bactérienne. Ces compositions contiennent une quantité thérapeutiquement efficace de sertaconazole, ou un sel pharmaceutiquement acceptable, un solvant ou un isomère de celui-ci ; ainsi qu'une quantité thérapeutiquement efficace d'au moins un composé choisi dans le groupe hydrocortisone, un sel pharmaceutiquement acceptable d'hydrocortisone, un composé de quinolone antibactérien, et des mélanges de ceux-ci.
• [EN] A SYSTEM FOR THE TREATMENT OF DERMATOLOGICAL INFECTIONS<br/>[FR] SYSTÈME POUR LE TRAITEMENT D'INFECTIONS DERMATOLOGIQUES
  申请人：SOL-GEL TECH LTD

  公开号：WO2016142946A1

  公开（公告）日：2016-09-15

  The present invention provides a system comprising econazole and mometasone, including uses and methods of treatment of dermatological infectious diseases, disorders and symptoms thereof.