(1S,3R)-3-(3-bromophenyl)-N-[(1R)-1-(4-fluoronaphthalen-1-yl)ethyl]cyclopentanamine | 1211473-71-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (1S,3R)-3-(3-bromophenyl)-N-[(1R)-1-(4-fluoronaphthalen-1-yl)ethyl]cyclopentanamine
• 英文别名: (1S,3R)-3-(3-bromophenyl)-N-[(1R)-1-(4-fluoronaphthalen-1-yl)ethyl]cyclopentan-1-amine
• CAS: 1211473-71-0
• 化学式: C₂₃H₂₃BrFN
• 分子量: 412.345
• InChiKey: DTSIGLJGGMUBIG-SUMDDJOVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• CYCLOALKYLAMINE DERIVATIVES
  申请人：Marumoto Shinji

  公开号：US20120295943A9

  公开（公告）日：2012-11-22

  Provided is a therapeutic agent for hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like, which has a CaSR activating (agonist) action. A compound represented by the following general formula (1): [wherein, Ar which is a partial structure in the general formula (1) represents a phenyl group or a naphthyl group; R 1a and R 1b are the same or different from each other, and represent a hydrogen atom, a halogeno group, or the like; R 2a and R 2b are the same or different from each other, and represent a hydrogen atom, a halogeno group, or the like; A represents a single bond, an oxygen atom, or the like; B represents a single bond, a C1-C4 alkanediyl group, or the like; Z represents a carboxyl group or a tetrazolyl group; and m represents an integer of 1 to 3] or a pharmacologically acceptable salt thereof.

  提供了一种治疗甲状旁腺功能亢进、肾性骨营养不良、高钙血症等疾病的治疗剂，具有CaSR激活（激动剂）作用。该化合物由以下通式（1）表示：[其中，通式（1）中的部分结构Ar表示苯基或萘基；R1a和R1b相同或不同，表示氢原子，卤素基团或类似物；R2a和R2b相同或不同，表示氢原子，卤素基团或类似物；A表示单键，氧原子或类似物；B表示单键，C1-C4烷二基基团或类似物；Z表示羧基或四唑基；m表示1至3的整数]或其药学上可接受的盐。
• CYCLOALKYLAMINE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2341044B1

  公开（公告）日：2014-02-26
• US9133140B2
  申请人：——

  公开号：US9133140B2

  公开（公告）日：2015-09-15