4-Amino-5-(pyrid-3-oxy)quinazoline | 215925-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Amino-5-(pyrid-3-oxy)quinazoline
• 英文别名: 5-Pyridin-3-yloxyquinazolin-4-amine
• CAS: 215925-86-3
• 化学式: C₁₃H₁₀N₄O
• 分子量: 238.249
• InChiKey: UIOFXSRYRHGWAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Formulations for hydrophobic pharmaceutical agents
  申请人：——

  公开号：US20010012844A1

  公开（公告）日：2001-08-09

  The present invention features formulations, including liquid, semi-solid or solid pharmaceutical formulations, that improve the oral bioavailability of hydrophobic pharmaceutical agents, such as quinazoline-, nitrothiazole-, and indolinone-based compounds. Also featured are formulations for parenteral delivery of such hydrophobic pharmaceutical agents, as well as methods of making and using both types of formulations.

  本发明涉及包括液体、半固体或固体制剂的配方，可以提高疏水性药物，如喹唑啉、硝基噻唑和吲哚酮类化合物的口服生物利用度。还包括适用于静脉注射递送这些疏水性药物的配方，以及制备和使用这两种类型配方的方法。
• Methods of modulating serine/threonine protein kinase function with quinazoline-based compounds
  申请人：——

  公开号：US20010014679A1

  公开（公告）日：2001-08-16

  The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with quinazoline-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to quinazoline compounds and pharmaceutical compositions comprising these compounds.

  本发明部分涉及使用基于喹唑啉的化合物调节丝氨酸/苏氨酸蛋白激酶功能的方法。该方法包括表达丝氨酸/苏氨酸蛋白激酶（例如RAF）的细胞。此外，本发明还描述了使用本发明所确定的化合物预防和治疗有关丝氨酸/苏氨酸蛋白激酶的异常情况的方法。此外，本发明还涉及喹唑啉化合物和包含这些化合物的制药组合物。
• METHODS OF MODULATING SERINE/THREONINE PROTEIN KINASE FUNCTION WITH QUINAZOLINE-BASED COMPOUNDS
  申请人：Sugen, Inc.

  公开号：EP0981519A1

  公开（公告）日：2000-03-01
• FORMULATIONS FOR HYDROPHOBIC PHARMACEUTICAL AGENTS
  申请人：Sugen, Inc.

  公开号：EP1014953A2

  公开（公告）日：2000-07-05
• US6204267B1
  申请人：——

  公开号：US6204267B1

  公开（公告）日：2001-03-20