| 1254368-09-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• CAS: 1254368-09-6
• 化学式: C₂₀H₂₁N₃O₇
• 分子量: 415.403
• InChiKey: BDFMKPWIUXSBOZ-ILBVQXBRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.48
• 重原子数：
  30.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  174.28
• 氢给体数：
  5.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  在 palladium 10% on activated carbon 氢气 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  [EN] 8-AZA TETRACYCLINE COMPOUNDS
  [FR] COMPOSÉS DE 8-AZA TÉTRACYCLINE

  摘要：

  本发明涉及一种由结构式（I）表示的化合物或其药用盐。结构式I的变量在此定义。还描述了包括结构式I化合物的药物组合物及其治疗用途。

  公开号：

  WO2010129055A1

文献信息

• 8-AZA Tetracycline Compounds
  申请人：Clark Roger B.

  公开号：US20120108569A1

  公开（公告）日：2012-05-03

  The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
• SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF
  申请人：President and Fellows of Harvard College

  公开号：US20140163238A1

  公开（公告）日：2014-06-12

  The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
• US8367654B2
  申请人：——

  公开号：US8367654B2

  公开（公告）日：2013-02-05
• US8828988B2
  申请人：——

  公开号：US8828988B2

  公开（公告）日：2014-09-09
• US9365493B2
  申请人：——

  公开号：US9365493B2

  公开（公告）日：2016-06-14